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August 12, 2008; 71 (7) Resident and Fellow Section

Teaching NeuroImage: MRI visualization of papilledema associated with cerebral sinovenous thrombosis in a child

Jennifer A. Zimmer, Bhuwan P. Garg, Darren P. O’Neill, Meredith R. Golomb
First published August 11, 2008, DOI: https://doi.org/10.1212/01.wnl.0000325016.18727.1f
Jennifer A. Zimmer
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Bhuwan P. Garg
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Darren P. O’Neill
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Meredith R. Golomb
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Teaching NeuroImage: MRI visualization of papilledema associated with cerebral sinovenous thrombosis in a child
Jennifer A. Zimmer, Bhuwan P. Garg, Darren P. O’Neill, Meredith R. Golomb
Neurology Aug 2008, 71 (7) e12-e13; DOI: 10.1212/01.wnl.0000325016.18727.1f

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A 3-year-old boy with ulcerative colitis and developmental delay presented with a 3-week history of headaches, emesis, and dehydration. His neurologic examination was nonfocal, but MR venogram revealed cerebral sinovenous thrombosis (figure). He was rehydrated and discharged on enoxaparin. Three months later he starting having difficulty reaching for objects and was running into walls. Repeat MRI and MR venogram demonstrated residual thrombosis and interval development of papilledema (figure). Papilledema was confirmed on funduscopic examination. CSF opening pressure was 37 cm H2O. When treatment with acetazolamide failed to control intracranial hypertension, he received a ventriculoperitoneal shunt.

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Figure MRI

A) Initial MR venography demonstrated partial thrombosis of the superior sagittal sinus, torcula, and proximal transverse sinuses (arrows). B) Follow-up MR venography at the time of visual worsening showed improvement in venous flow, with mild residual thrombosis. C) Fast-spin echo T2-weighted axial imaging demonstrated reversed optic nerve cupping in the right eye with posterior scleral flattening and protrusion of optic nerve papilla into the globe (arrow) (subsequent image on MRI demonstrated similar findings in the left eye). D) Close-up of right eye seen in C. MRI data: (A and B) repetition time (TR) 33.3 msec, echo time (TE) 6.9 msec, ST 1.5 mm; (C and D) TR 3,500 msec, TE 95 msec, ST 5.0 mm.

Inflammatory bowel disease (IBD) is a risk factor for venous thromboembolism.1 Attempts to identify a unifying genetic risk factor for thromboembolism in patients with IBD have yielded conflicting results. Endothelial damage from IBD, leading to platelet activation and release of inflammatory mediators by platelets, may play a role.2 Our patient’s prothrombotic workup demonstrated only heterozygosity for both the methylene tetrahydrofolate reductase (MTHFR) C677T and plasminogen activator inhibitor (PAI)-1 4G (also known as SERPINE 1) mutations.

ACKNOWLEDGMENT

The authors thank Dr. Michelle Nwosu for technical assistance.

Footnotes

  • Dr. Golomb is supported by the following grants: NIH NINDS K23 NS 048024 and Clarian Values Fund grant VFR-171.

    Disclosure: The authors report no disclosures.

  • Series editor: Mitchell S.V. Elkind MD, MS, Section Editor

REFERENCES

  1. 1.↵
    Miehsler W, Reinisch W, Valic E, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 2004;53:542–8.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    Standridge S, de los Reyes E. Inflammatory bowel disease and cerebrovascular arterial and venous thromboembolic events in 4 pediatric patients: a case series and review of the literature. J Child Neurol 2008;23:59–66.
    OpenUrlAbstract/FREE Full Text
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