Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

March 10, 2009; 72 (10) Articles

Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood

Yann Mikaeloff, Guillaume Caridade, Samy Suissa, Marc Tardieu
First published October 8, 2008, DOI: https://doi.org/10.1212/01.wnl.0000335762.42177.07
Yann Mikaeloff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guillaume Caridade
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samy Suissa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marc Tardieu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff, Guillaume Caridade, Samy Suissa, Marc Tardieu
Neurology Mar 2009, 72 (10) 873-880; DOI: 10.1212/01.wnl.0000335762.42177.07

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
946

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Background: The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated, with studies reporting conflicting findings.

Methods: We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994–2003). Each case was matched on age, sex, and geographic location to up to 12 controls, randomly selected from the general population. Information on vaccinations was confirmed by a copy of the vaccination certificate. The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression.

Results: The rates of HB vaccination in the 3 years before the index date were 24.4% for the 349 cases and 27.3% for their 2,941 matched controls. HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR, 0.74; 0.54–1.02), neither >3 years nor as a function of the number of injections or brand type. When the analysis was restricted to subjects compliant with vaccination, HB vaccine exposure >3 years before index date was associated with an increased trend (1.50; 0.93–2.43), essentially from the Engerix B vaccine (1.74; 1.03–2.95). The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (2.77; 1.23–6.24).

Conclusions: Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood. However, the Engerix B vaccine appears to increase this risk, particularly for confirmed multiple sclerosis, in the longer term. Our results require confirmation in future studies.

ADEM = acute disseminated encephalomyelitis; BCG = Bacille Calmette–Guèrin; HB = hepatitis B; MS = multiple sclerosis; OR = odds ratio.

Footnotes

  • Editorial, page 870

    e-Pub ahead of print on October 8, 2008, at www.neurology.org.

    Funded by grants from the “Agence Française de Sécurité Sanitaire des Produits de Santé” (AFSSAPS), the “Agence Nationale de Recherche sur le SIDA et les hépatites” (ANRS), and the French Ministry of Health by a grant from the “Projet Hospitalier de Recherche Clinique” and by the “Direction Générale de la Santé.” S. Suissa holds a Distinguished Scientist award from the Canadian Institutes of Health Research (CIHR).

    Disclosure: The authors report no disclosures.

    Received March 21, 2008. Accepted in final form August 6, 2008.

  • Embedded Image

View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

  • Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
    • Michel Lievre, Lyon 1 University, Service de Pharmacologie Clinique, Faculté de Médecine, rue Guillaume Paradin, 69008 Lyon, Franceml@upcl.univ-lyon1.fr
    • Members of the Epidemiology working group of the French pharmacovigilance commission: Dominique Costagliola, Stephen Evans, Annie Fourrier, Jean-Louis Imbs, Daniel Levy-Bruhl, Louis Merle, Joelle Micallef, Emmanuel Oger
    Submitted March 10, 2009
  • Editor's Note
    • Richard J. Kryscio, PhD, Associate Editor, Biostatistics, Neurologykpieper@neurology.org
    Submitted March 10, 2009
  • Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
    • Alain Braillon, Department of Public Health, Hôpital Nord, 80054 Amiens CEDEX 1, Francebraillon.alain@chu-amiens.fr
    • Gérard Dubois
    Submitted December 05, 2008
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENT
    • Appendix 1
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

SARS-CoV-2 Vaccination Safety in Guillain-Barré Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy

Dr. Jeffrey Allen and Dr. Nicholas Purcell

► Watch

Related Articles

  • Hepatitis vaccines and pediatric multiple sclerosisDoes timing or type matter?

Topics Discussed

  • All Pediatric
  • Case control studies
  • Multiple sclerosis
  • Acute disseminated encephalomyelitis

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Articles
    Recombinant hepatitis B vaccine and the risk of multiple sclerosis
    A prospective study
    Miguel A. Hernán, Susan S. Jick, Michael J. Olek et al.
    Neurology, September 13, 2004
  • Editorials
    Hepatitis vaccines and pediatric multiple sclerosis
    Does timing or type matter?
    Jayne M. Ness, James F. Bale, Jr et al.
    Neurology, December 17, 2008
  • Special Article
    Practice guideline update summary: Vaccine-preventable infections and immunization in multiple sclerosis
    Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
    Mauricio F. Farez, Jorge Correale, Melissa J. Armstrong et al.
    Neurology, August 28, 2019
  • Correspondence
    HEPATITIS B VACCINE AND THE RISK OF CNS INFLAMMATORY DEMYELINATION IN CHILDHOOD
    M. Lièvre, Members of the Epidemiology Working Group of the French Pharmacovigilance Commission, D. Costagliola et al.
    Neurology, October 26, 2009
Neurology: 100 (13)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise