AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

M. L. Evatt; M. R. DeLong; W. B. Grant; J. J. Cannell; V. Tangpricha

doi:10.1212/WNL.0b013e3181af0b95

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To the Editor:

We find the report by Bromley et al.¹ of an increased incidence of autism spectrum disorders in the offspring of mothers taking antiepileptic drugs (AEDs) during pregnancy intriguing and suggest low vitamin D as a possible mechanism deserving further investigation.

Several AEDs are known to bind to the pregnane X receptor to increase the catabolism of vitamin D by upregulating the mitochondrial enzyme CYP24. AEDs, including valproic acid, are known to decrease 25-hydroxyvitamin D levels.² It has been reported that babies born to women taking AEDs during pregnancy had significantly lower 25-hydroxyvitamin D concentrations compared to healthy control newborns.³ Vitamin …

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AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

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