AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS
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To the Editor:
We find the report by Bromley et al.1 of an increased incidence of autism spectrum disorders in the offspring of mothers taking antiepileptic drugs (AEDs) during pregnancy intriguing and suggest low vitamin D as a possible mechanism deserving further investigation.
Several AEDs are known to bind to the pregnane X receptor to increase the catabolism of vitamin D by upregulating the mitochondrial enzyme CYP24. AEDs, including valproic acid, are known to decrease 25-hydroxyvitamin D levels.2 It has been reported that babies born to women taking AEDs during pregnancy had significantly lower 25-hydroxyvitamin D concentrations compared to healthy control newborns.3 Vitamin …
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