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To the Editor:
Cole et al.1 described boys with attention-deficit hyperactivity disorder (ADHD) showing little age-related improvement in motor speed and subtle signs of motor function while girls with ADHD appear to improve at a comparable rate to normal girls.
In this study, stimulant medication was omitted on the day of testing and the previous day. This is important because stimulant medication has been shown to reduce the rate of movements in children with ADHD performing cognitive tasks.2,3 In addition, differential effects of methylphenidate and dexamphetamine on the motor activity levels of hyperactive children have been described.2
Despite the 24-hour washout period, the history of treatment with stimulant medication may be an important consideration. In this context it is vital because the therapeutic effect of stimulant medication is wearing off and there is a rebound period. This results in a measurable increase in hyperactivity which may persist overnight and until the first dose of medication is given the following …
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