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The desirability of a safe and inexpensive medical treatment that can improve a patient's health and sense of well-being has resulted in the growing use of complementary and alternative medicine (CAM) worldwide. Once considered fringe medicine, meditation, yoga, and other mind-body therapies—the most commonly practiced form of CAM—are increasingly practiced by patients with chronic neurologic disorders, such as multiple sclerosis (MS).1 In a recent survey, up to 67% of patients with MS reported the current use of at least one form of CAM, with most regarding their practice as complementary rather than as an alternative to conventional medicine.2 Despite the popularity of CAM, there is a paucity of well-designed clinical trials evaluating its use in MS; most studies are hampered by small sample size or lack of a control arm.
The study by Grossman et al.3 in this issue of Neurology® was a randomized, single-blind, controlled trial that investigated the effects of mindfulness-based meditation compared to usual care on depression and quality of life measures in 150 patients with MS. Patients with remitting-relapsing and secondary progressive MS with an Expanded Disability Status …
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