Prevalence of MRI-defined recent silent ischemia and associated bleeding risk with thrombolysis
The authors analyzed the fluid-attenuated inversion recovery/diffusion-weighted imaging obtained before IV thrombolysis in 115 patients to search for MRI-defined recent silent ischemia (RSI). RSI was identified in 18% of pretreatment MRI; however, the presence of RSI was not associated with an increased risk of asymptomatic or symptomatic hemorrhagic transformation.
Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure
The authors investigated dopaminergic function using FDOPA PET in 20 asymptomatic, manganese-exposed welders, 20 subjects with idiopathic Parkinson disease, and 20 normal controls. Caudate Kis was lower in welders compared with control subjects, demonstrating that asymptomatic, manganese-exposed welders have a unique pattern of dopaminergic dysfunction.
See p. 1296
From editorialist W.R. Wayne Martin: “The study provides an excellent example of the utility of FDOPA/PET in the assessment of potential dopaminergic changes occurring in asymptomatic individuals. It is important to remember, however, that PD remains a clinical diagnosis centered on the presence of the characteristic neurologic signs.”
See p. 1286
Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab
The authors examined 10 patients with neuromyelitis optica who were treated up to 5 times with rituximab as a second-line therapy. They found that retreatment should be applied before reappearance of circulating B cells and does provide stabilization in most patients.
See p. 1310
fMRI language dominance and FDG-PET hypometabolism
The authors examined the association of left temporal hypometabolism with laterality of fMRI language task activation in 30 patients with temporal lobe epilepsy. They did not find evidence of impaired BOLD response in hypometabolic cortex. Regional hypometabolism appeared to be a marker for the temporal lobe dysfunction that leads to displacement of language function.
See p. 1322
Long-term intellectual outcome after temporal lobe surgery in childhood
The authors report the follow-up of 42 children who underwent temporal lobe surgery. At follow-up, 86% of the surgical group were seizure-free and 57% were no longer taking antiepileptic medication. Developmental catch-up (IQ increment) was seen in children who became seizure-free after neurosurgical treatment.
See p. 1330
Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children
Gingival overgrowth is a common, cosmetically and medically important adverse effect of phenytoin therapy. This study found significant reduction in the incidence of phenytoin-induced gingival overgrowth in 62 participants receiving daily oral folic acid (0.5 mg/day for 6 months) as compared to a placebo-control group with 58 participants.
See p. 1338
VIEWS & REVIEWS
Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links
This review proposes a conceptual framework involving the amyloid-β peptide, Aβ precursor protein, and fragile X mental retardation protein based on experimental evidence. The authors speculate that the anabolic effect of sAPPα contributes to the state of excess that underlies fragile X syndrome and autism, especially in younger children.
See p. 1344
NB: Reflections for April: “The silent witness and Charcot's hat,” see p. 1358. To check out other Reflections, point your browser to http://www.neurology.org. The Green Journal is celebrating an important anniversary in 2011—it is 60 years old. Check out some of the activities this week at the AAN Meeting.
- Copyright © 2011 by AAN Enterprises, Inc.
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- Prevalence of MRI-defined recent silent ischemia and associated bleeding risk with thrombolysis
- Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure
- Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab
- fMRI language dominance and FDG-PET hypometabolism
- Long-term intellectual outcome after temporal lobe surgery in childhood
- Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children
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