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February 08, 2011; 76 (6) Articles

Metabolic syndrome and cognitive decline in French elders

The Three-City Study

C. Raffaitin, C. Féart, M. Le Goff, H. Amieva, C. Helmer, T.N. Akbaraly, C. Tzourio, H. Gin, P. Barberger-Gateau
First published February 2, 2011, DOI: https://doi.org/10.1212/WNL.0b013e31820b7656
C. Raffaitin
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C. Féart
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M. Le Goff
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H. Amieva
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C. Helmer
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T.N. Akbaraly
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C. Tzourio
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H. Gin
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P. Barberger-Gateau
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Citation
Metabolic syndrome and cognitive decline in French elders
The Three-City Study
C. Raffaitin, C. Féart, M. Le Goff, H. Amieva, C. Helmer, T.N. Akbaraly, C. Tzourio, H. Gin, P. Barberger-Gateau
Neurology Feb 2011, 76 (6) 518-525; DOI: 10.1212/WNL.0b013e31820b7656

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Abstract

Objective: To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.

Methods: Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program–Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.

Results: MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08–1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01–1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95–1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.

Conclusions: MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.

Footnotes

  • Study funding: The 3C Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the Institut de Santé Publique et Développement (ISPED) of the Victor Segalen Bordeaux 2 University, and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Mutuelle Générale de l'Education Nationale, Institut de la Longévité, Regional Councils of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques.” The Lille Genopole was supported by an unconditional grant from Eisai. Mélanie Le Goff worked with the financial support of the “ANR–Agence Nationale de la Recherche–The French National Research Agency” under the “Programme National de Recherche en Alimentation et Nutrition Humaine,” project COGINUT ANR-06-PNRA-005.

  • 3C
    Three-City Study
    AD
    Alzheimer disease
    BVRT
    Benton Visual Retention Test
    CES-D
    Center for Epidemiologic Studies–Depression
    DSM-IV
    Diagnostic and Statistical Manual of Mental Disorders, 4th edition
    HDL
    high-density lipoprotein
    HR
    hazard ratio
    IST
    Isaacs Set Test
    MetS
    metabolic syndrome
    MMSE
    Mini-Mental State Examination
    NCEP-ATP III
    National Cholesterol Education Program–Adult Treatment Panel III

  • Received June 9, 2010.
  • Accepted October 13, 2010.
  • Copyright © 2011 by AAN Enterprises, Inc.
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