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February 08, 2011; 76 (6) Articles

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions

E.C. Tallantyre, J.E. Dixon, I. Donaldson, T. Owens, P.S. Morgan, P.G. Morris, N. Evangelou
First published February 7, 2011, DOI: https://doi.org/10.1212/WNL.0b013e31820b7630
E.C. Tallantyre
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J.E. Dixon
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I. Donaldson
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T. Owens
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P.S. Morgan
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P.G. Morris
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Citation
Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions
E.C. Tallantyre, J.E. Dixon, I. Donaldson, T. Owens, P.S. Morgan, P.G. Morris, N. Evangelou
Neurology Feb 2011, 76 (6) 534-539; DOI: 10.1212/WNL.0b013e31820b7630

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Abstract

Objectives: To investigate whether multiple sclerosis (MS) and non-MS white matter brain lesions can be distinguished by their appearance on 7 T T2*-weighted MRI.

Methods: This was an observational study of 28 patients with MS and 17 patients with cerebral white matter lesions who did not have MS. Subjects were imaged using 7 T T2*-weighted imaging. White matter lesions were identified and analyzed for volume, location, and perivenous appearance.

Results: Out of 901 lesions identified in patients with MS, 80% were perivenous. In comparison, 19% of 428 lesions identified in patients without MS had a perivenous appearance. Seven-Tesla T2*-weighted MRI reliably distinguished all patients with clinically definite MS (>40% lesions appeared perivenous) from those without clinical MS (<40% lesions appeared perivenous). Perivenous lesion appearance was more predictive of MS (odds ratio [OR] 14, p < 0.001) than subcortical or periventricular lesion location (OR 4.5, p < 0.001, and OR 2.4, p = 0.009). Perivenous lesion appearance was observed with a similar frequency in patients with clinically isolated syndrome of demyelination and in early (gadolinium-enhancing) MS lesions.

Conclusion: Perivenous lesion location on 7 T T2*-weighted imaging is predictive of the presence of demyelination. Optimization of this imaging technique at lower magnetic resonance field strengths would offer benefit for the diagnosis of MS.

Footnotes

  • Study funding: Supported by MRC/Multiple Sclerosis Society UK (G0700584).

  • CIS
    clinically isolated syndrome
    MS
    multiple sclerosis
    OR
    odds ratio
    WM
    white matter

  • Received May 3, 2010.
  • Accepted October 1, 2010.
  • Copyright © 2011 by AAN Enterprises, Inc.
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  • All Imaging
  • All Demyelinating disease (CNS)
  • Multiple sclerosis
  • MRI
  • Clinical trials Observational study (Cohort, Case control)

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