A 49-year-old man with 10 years of intranasal cocaine use presented with dysphagia. Neurologic examination demonstrated bilateral sixth nerve palsies. Brain MRI showed erosion of the sphenoid sinus walls and a defect in the skull base; the resulting path between the nasal cavity and brainstem permitted rhomboencephalitis and clival osteomyelitis (figure 1). Clival cultures grew methicillin-resistant Staphylococcus aureus. IV antibiotics were administered and switched to oral after 6 weeks. Repeat MRI showed decreased T2 fluid-attenuated inversion recovery brainstem hyperintensity (figure 2). Antibiotics will be used for at least 1 year; surgical reconstruction of the skull base will depend on his abstinence from cocaine.
Sagittal T2 (A), axial T2 fluid-attenuated inversion recovery (B), and sagittal T1 with contrast MRI (C) show a large bony defect in the skull base with erosion of the sphenoid sinus walls and perforated nasal septum. There is abnormal T2 hyperintensity and enhancement in the brainstem with clival erosion (arrow where most severe) and marrow enhancement.
Axial T2 fluid-attenuated inversion recovery MRI of the brain demonstrates decreased T2 fluid-attenuated inversion recovery hyperintensity in the medulla following 6 weeks of IV antibiotics.
Footnotes
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Author contributions: Jordan S. Dubow: involved in conceptualization of paper and drafting the manuscript. Samuel Singer: involved in revising the manuscript. Alan Z. Segal: involved in revising the manuscript.
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Disclosure: Dr. Dubow and Dr. Singer report no disclosures. Dr. Segal serves on the speakers' bureau for Boehringer Ingelheim.
- Copyright © 2011 by AAN Enterprises, Inc.
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