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Abstract
Objective: We evaluated quantitative EEG (QEEG) measures as predictive biomarkers for the development of dementia in Parkinson disease (PD). Preliminary work shows that QEEG measures correlate with current PD cognitive state. A reliable predictive QEEG biomarker for PD dementia (PD-D) incidence would be valuable for studying PD-D, including treatment trials aimed at preventing cognitive decline in PD.
Methods: A cohort of subjects with PD in our brain donation program utilizes annual premortem longitudinal movement and cognitive evaluation. These subjects also undergo biennial EEG recording. EEG from subjects with PD without dementia with follow-up cognitive evaluation was analyzed for QEEG measures of background rhythm frequency and relative power in δ, θ, α, and β bands. The relationship between the time to onset of dementia and QEEG and other possible predictors was assessed by using Cox regression.
Results: The hazard of developing dementia was 13 times higher for those with low background rhythm frequency (lower than the grand median of 8.5 Hz) than for those with high background rhythm frequency (p < 0.001). Hazard ratios (HRs) were also significant for > median θ bandpower (HR = 3.0; p = 0.004) compared to below, and for certain neuropsychological measures. The HRs for δ, α, and β bandpower as well as baseline demographic and clinical characteristics were not significant.
Conclusion: The QEEG measures of background rhythm frequency and relative power in the θ band are potential predictive biomarkers for dementia incidence in PD. These QEEG biomarkers may be useful in complementing neuropsychological testing for studying PD-D incidence.
Footnotes
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Study funding: Supported by Beth and Larry Johnson, Mayo Clinic Foundation for Medical Research, Michael J Fox Foundation for Parkinson's Research (Prescott Family Initiative), Arizona Disease Control Research Commission (contracts 04-800, 4001, 05-901), and the NIH (P30 AG019610).
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- AVLT-LTM=
- long-term memory score on the Auditory Verbal Learning Test;
- BRF=
- background rhythm frequency;
- COWAT=
- Controlled Oral Word Association Test;
- DSM-IV=
- Diagnostic and Statistical Manual of Mental Disorders, 4th edition;
- FFT=
- fast Fourier transform;
- HR=
- hazard ratio;
- JLO=
- Judgment of Line Orientation;
- MMSE=
- Mini-Mental State Examination;
- PD=
- Parkinson disease;
- PD-D=
- Parkinson disease with dementia;
- PD-MCI=
- Parkinson disease with mild cognitive impairment;
- QEEG=
- quantitative EEG;
- WAIS=
- Wechsler Adult Intelligence Scale
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Editorial, page 94
- Received September 3, 2010.
- Accepted January 11, 2011.
- Copyright © 2011 by AAN Enterprises, Inc.
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