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July 19, 2011; 77 (3) Articles

Nontraditional risk factors combine to predict Alzheimer disease and dementia

Xiaowei Song, Arnold Mitnitski, Kenneth Rockwood
First published July 13, 2011, DOI: https://doi.org/10.1212/WNL.0b013e318225c6bc
Xiaowei Song
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Arnold Mitnitski
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Kenneth Rockwood
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Nontraditional risk factors combine to predict Alzheimer disease and dementia
Xiaowei Song, Arnold Mitnitski, Kenneth Rockwood
Neurology Jul 2011, 77 (3) 227-234; DOI: 10.1212/WNL.0b013e318225c6bc

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    Figure 1 Rates of death and Alzheimer disease (AD) dementia

    (A) Five-year (circles) and 10-year (squares) rates of death as a function of the frailty index of nontraditional risk factors (FI-NTRF). (B) Rate of AD after 5 years (circles) and 10 years (squares), and rates of all types of dementia after 5 years (stars) and 10 years (triangles) as a function of the FI-NTRF. Symbols represent observational data as averaged by each 0.03 increment of the FI-NTRF.

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    Figure 2 Receiver operating characteristic (ROC) curves

    ROC curves showing the performance of the frailty index of nontraditional risk factors in predicting individuals who died vs those who survived and in predicting individuals who developed Alzheimer disease (AD) or all types of dementia vs those who remained cognitively healthy. The areas under the curve (mean AUC ± standard error) were 0.68 ± 0.02 for death within 5 years (black line); AUC = 0.65 ± 0.01 for death within 10 years (blue line); AUC = 0.64 ± 0.03 for AD within 5 years (red line); AUC = 0.66 ± 0.03 for AD within 10 years (orange line); AUC = 0.64 ± 0.03 for dementia within 5 years (green line); AUC = 0.66 ± 0.03 for dementia within 10 years (purple line). The diagonal line indicates AUC = 0.50.

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    Two tables and one figure; three Word documents.

    Neurology® data supplements are not copyedited before publication.
    Copyright © 2011 by AAN Enterprises, Inc.

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    • Table e-1 - Word document.
    • Table e-2 - Word document.
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