Nontraditional risk factors combine to predict Alzheimer disease and dementia

Xiaowei Song; Arnold Mitnitski; Kenneth Rockwood

doi:10.1212/WNL.0b013e318225c6bc

Full PDF

Citation

Permissions

Make Comment

See Comments

Downloads

3299

Article Figures & Data

Figures

Tables
Additional Files

Download figure

Open in new tab

Download powerpoint

Figure 1 Rates of death and Alzheimer disease (AD) dementia
(A) Five-year (circles) and 10-year (squares) rates of death as a function of the frailty index of nontraditional risk factors (FI-NTRF). (B) Rate of AD after 5 years (circles) and 10 years (squares), and rates of all types of dementia after 5 years (stars) and 10 years (triangles) as a function of the FI-NTRF. Symbols represent observational data as averaged by each 0.03 increment of the FI-NTRF.
Download figure

Open in new tab

Download powerpoint

Figure 2 Receiver operating characteristic (ROC) curves
ROC curves showing the performance of the frailty index of nontraditional risk factors in predicting individuals who died vs those who survived and in predicting individuals who developed Alzheimer disease (AD) or all types of dementia vs those who remained cognitively healthy. The areas under the curve (mean AUC ± standard error) were 0.68 ± 0.02 for death within 5 years (black line); AUC = 0.65 ± 0.01 for death within 10 years (blue line); AUC = 0.64 ± 0.03 for AD within 5 years (red line); AUC = 0.66 ± 0.03 for AD within 10 years (orange line); AUC = 0.64 ± 0.03 for dementia within 5 years (green line); AUC = 0.66 ± 0.03 for dementia within 10 years (purple line). The diagonal line indicates AUC = 0.50.

Additional Files

Figures
Tables

Data Supplement

Two tables and one figure; three Word documents.

Neurology® data supplements are not copyedited before publication.
Copyright © 2011 by AAN Enterprises, Inc.

Files in this Data Supplement:

Table e-1 - Word document.
Table e-2 - Word document.
Figure e-1 - Word document.

Letters: Rapid online correspondence

No comments have been published for this article.

Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
Submit only on articles published within 6 months of issue date.
Do not be redundant. Read any comments already posted on the article prior to submission.
Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

Title *

Author Information

NOTE: The first author must also be the corresponding author of the comment.

Authors
First Name and Middle Initial * First or given name, e.g. 'Peter'. Last Name * Your last, or family, name, e.g. 'MacMoody'. Email Address * Your email address, e.g. [email protected] Occupation * Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation * Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Publishing Agreement

I, the first and corresponding author, verify that I have read the contents of the PUBLISHING AGREEMENT form. *

I, the first and corresponding author, verify my disclosures and those of my co-authors are up to date at http://submit.neurology.org. *

Select only one of the three options below: *

I am an Author of this Work, and the Work was prepared on my own time - not as part of my duties as an employee.

I prepared (or cooperated in the preparation of) the Work as part of my duties as an employee, and the Work is, therefore, a "work made for hire", as defined by the United States Copyright Act of 1976, as amended.

I prepared (or participated in the preparation of) the Work as part of my official duties as an officer or employee of the United States Government.

NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Main menu

User menu

Search

Nontraditional risk factors combine to predict Alzheimer disease and dementia

Citation Manager Formats