Total daily physical activity and the risk of AD and cognitive decline in older adults

A.S. Buchman; P.A. Boyle; L. Yu; R.C. Shah; R.S. Wilson; D.A. Bennett

doi:10.1212/WNL.0b013e3182535d35

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Abstract

Objective: Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline.

Methods: Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests.

Results: During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273–0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007).

Conclusions: A higher level of total daily physical activity is associated with a reduced risk of AD.

GLOSSARY

AD=: Alzheimer disease;
BMI=: body mass index;
CES-D=: Center for Epidemiologic Studies Depression;
CI=: confidence interval;
HR=: hazard ratio

Footnotes

Study funding: Supported by the NIH/NIA (R01AG17917, R01AG24480, and R01AG34374), the Illinois Department of Public Health, and the Robert C. Borwell Endowment Fund.
Editorial, page 1290

Received September 13, 2011.
Accepted December 8, 2011.

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Letters: Rapid online correspondence

Total Daily Activity and Incident AD
Aron S. Buchman, MD, Rush University Medical Centeraron_s_buchman@rush.edu

Aron S. Buchman,MD, Lei Yu, PhD, Patricia A. Boyle, PhD, Robert S. Wilson, PhD, David A. Bennett, MD, Chicago, IL
Submitted May 09, 2012
Longer follow up
Kazuo Abe, Professor, Osaka Health Science Universityabe_neurology@85.alumni.u-tokyo.ac.jp

Kazuo Abe, Osaka, Japan
Submitted May 01, 2012

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