Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

April 26, 2012; 78 (1 Supplement) April 26,2012

Effects of Bradykinesia and Hypokinesia on Falls in Parkinson's Disease (P06.048)

Abraham Lieberman, Narayanan Krishnamurthi, Anthony Santiago, Rohit Dhall, Guillermo Moguel-Cobos, Arshia Sadreddin, Sameea Husain, Naomi Salins, Di Pan, Sara Dhanani
First published February 8, 2016,
Abraham Lieberman
1 Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Narayanan Krishnamurthi
2Muhammad Ali Parkinson Center Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anthony Santiago
3 Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rohit Dhall
4 Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guillermo Moguel-Cobos
5 Barrow Neurological Institute Gilbert AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arshia Sadreddin
6 Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sameea Husain
7 Barrow Neurological Institute Scottsdale AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naomi Salins
8 Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Di Pan
9Biomedical Informatics Arizona State University Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sara Dhanani
10Muhammad Ali Parkinson Center Barrow Neurological Institute Phoenix AZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Effects of Bradykinesia and Hypokinesia on Falls in Parkinson's Disease (P06.048)
Abraham Lieberman, Narayanan Krishnamurthi, Anthony Santiago, Rohit Dhall, Guillermo Moguel-Cobos, Arshia Sadreddin, Sameea Husain, Naomi Salins, Di Pan, Sara Dhanani
Neurology Apr 2012, 78 (1 Supplement) P06.048;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: Falls, with serious injuries, are a major problem in Parkinson disease (PD). In this study, the influence of body bradykinesia on falls in PD was investigated.

Background Bradykinesia is a complex consisting of slowness of movement (also called bradykinesia), hypokinesia (small or decreasing amplitude movement), and akinesia (inability to initiate movement). Bradykinesia (the complex) leads to motor tasks difficulties and its effect on falls in PD is unclear.

Design/Methods: We assessed slowness of movement (bradykinesia) and hypokinesia in 103 consecutive non-demented PD patients in medication-on state, of them 17 had ≥ 3 falls per month (fallers). Hypokinesia was assessed by the time taken for waist bending (WB) ten times in the sitting position and bradykinesia was assessed by Unified Parkinson's Disease Rating Scale (UPDRS) score (item 3.14). The t-test and chi-square tests were used to compare appropriate variables and a logistic regression model was constructed to predict sensitivities and specificities.

Results: Fifty-one patients had a bradykinesia score of ≥ 2 and 52 of 103 patients took more than 21 seconds (mean time taken across subjects) to complete WB ten times. The 17 fallers had a higher UPDRS motor score. A significantly higher number of fallers had a bradykinesia score of ≥ 2 (88.2%) and had a WB time > 21seconds (76.5%). Bradykinesia predicted falls with 88.2% sensitivity and 72.1% specificity and WB time predicted falls with 76.5% sensitivity and 55.8% specificity. The combination of WB time and bradykinesia predicted falls with 76.5% sensitivity and 82.6% specificity. Motor UPDRS scores, WB time, and bradykinesia were improved by medication in 10 patients who underwent medication-on/off testing.

Conclusions: Falls can be predicted by a combination of bradykinesia and hypokinesia. As both respond to dopaminergic drugs (and deep brain stimulation) both these should be considered in managing patients with falls.

Disclosure: Dr. Lieberman has nothing to disclose. Dr. Krishnamurthi has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. Dhall has received personal compensation for activities with Teva Pharmacuticals as a speaker. Dr. Moguel-Cobos has nothing to disclose. Dr. Sadreddin has nothing to disclose. Dr. Husain has nothing to disclose. Dr. Salins has nothing to disclose. Dr. Pan has nothing to disclose. Dr. Dhanani has nothing to disclose.

Thursday, April 26 2012, 07:30 am-12:00 pm

  • Copyright © 2011 by AAN Enterprises, Inc.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 96 (8)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise