Comparative safety of antiepileptic drugs during pregnancy
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Article Information
- Received August 30, 2011
- Accepted January 25, 2012
- First Published May 2, 2012.
Article Versions
- Previous version (May 2, 2012 - 13:01).
- You are viewing the most recent version of this article.
Author Disclosures
- S. Hernández-Díaz, MD, DrPH,
- C.R. Smith, MPH,
- A. Shen, MPH,
- R. Mittendorf, MD, DrPH,
- W.A. Hauser, MD,
- M. Yerby, MD,
- L.B. Holmes, MD and
- For the North American AED Pregnancy Registry
- S. Hernández-Díaz, MD, DrPH,
Served as scientific advisory board for Novartis and GSK Pregnancy Registries.
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Consultant for Data safety monitory board for Novartis.
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Salary support (2.5-5%) from funds provided by sponsors of the North American AED Pregnancy Registry: Abbott, Eisai, Novartis, Ortho-McNeil, Pfizer and Sunovion Pharmaceuticals.
NIH R01 HD046595-01A1. (MPI: Hernández-Díaz) Teratogenicity of Drugs Commonly Used in Pregnancy. National Institute of Child and Human Development. 2005- 2013 NIH R01 HD056940-01A2. (MPI: Hernández-Díaz) Assessment of Infant Outcomes after in utero Exposure to Antiretroviral Therapy. 2009-2012. NIH R01 HD059861-01A1 National Institute of Environmental Health Sciences. (MPI: Hernández-Díaz) Phthalates in Medications and the Risk of Male Genital Malformations. 2009-2013. AHRQ (MPI: Hernández-Díaz) Anti-Depressants during Pregnancy Postpartum: Safety and Effectiveness. 2009-2014. NIH U01 HD52104-01. NICHD.(PI: Van Dyke) Pediatric HIV/AIDS Cohort Study (PHACS) – Coordination Center. 2005- 2011.
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- C.R. Smith, MPH,
1) National Pregnancy Registry for Atypical Antipsychotics
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1) Abbott 2) Eisai 3) Novartis 4) Ortho-McNeil 5) Pfizer 6) Sunovion 7) Aurobindo 8) Dr Reddy’s Lab 9) GSK 10) Sanoz 11) Teva
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- A. Shen, MPH,
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Received financial assistance from Tufts University (while a MPH student) to attend and present at the 2010 American Public Health Association annual meeting.
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1) Abbott 2) Eisai 3) Novartis 4) Ortho-McNeil 5) Pfizer 6) Sunovion 7) Aurobindo 8) Dr Reddy’s Labs 9) GSK 10) Sandoz 11) Teva
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- R. Mittendorf, MD, DrPH,
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Current Health Reviews for Women, 2002-2011
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Australian Research Centre for Health of Women and Babies, Adelaide, SA. AMICABLE (Antenatal Magnesium IPD International Collaboration: Assessing the Benefits for Babies using the Best Level of Evidence). Co-Principal Investigator.
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- W.A. Hauser, MD,
DSMB NINDS neurocysticercosis treatment King Pharma Pharma diazepam injector DSMB Cephalon
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Editorial board Acta Neurologica Scandinavia 2000 present Editorial board Neuroepidemiology 2005 present Editorial board Epilepsy Research 2000 present
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1. Pfizer, Consultant, 2010 2. Neuropace Consultant 2011
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Developmental disabilities in Children with epilepsy PI David Lindenbaum, University of Kansas, Lawrence. Consultant CDC 2008-2011 INCIDENCE AND PROGNOSIS OF EPILEPSY IN HARLEM, NY: CDC PI: Dale Hesdorffer Grant #: 1 U48 DP001916-01 coinvestigator S109/30/09 - 09/29/14 FAA consultant neurologist
Mayo Clinic, Senior Visiting Scientist, 1984 present
Hotchkiss Neurological Institute, external reviewer 2008- 2010
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FAA Consultant
- M. Yerby, MD,
North American AED and Pregnancy Registry - Non Profit entity Speakers’ Bureaus: Lundbeck Speaker’s bureau UCB Speaker’s bureau
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Clinical trial support from Vanquix, and UCB
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- L.B. Holmes, MD and
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Abbott, Eisai, Novartis, Ortho McNeil, Pfizer and Sunovion
Supported, in part, by a subcontract from the Center for Birth Defects Research and Prevention in the Massachusetts Department of Public Health, Boston, MA
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- For the North American AED Pregnancy Registry
- North American AED (Antiepileptic Drug) Pregnancy RegistryScientific Advisory Committee
- North American AED (Antiepileptic Drug) Pregnancy RegistryScientific Advisory Committee
- North American AED Pregnancy Registry
- North American AED Pregnancy Registry
- From the Department of Epidemiology (S.H.-D., C.R.S.), Harvard School of Public Health, Boston, MA; North American AED Pregnancy Registry (A.S., L.B.H.), MassGeneral Hospital for Children, Boston, MA; Loyola University Health System (R.M.), Chicago, IL; College of Physicians and Surgeons and Mailman School of Public Health (W.A.H.), Columbia University, New York, NY; and Oregon Health and Science University (M.Y.), Portland, OR.
- Correspondence & reprint requests to Dr. Hernández-Díaz: shernan{at}hsph.harvard.edu
Article usage
Cited By...
Letters: Rapid online correspondence
- Response to Maheshwari et al.
- Sonia Hernandez-Diaz, Associate Professor, Harvard School of Public Healthshernan@hsph.harvard.edu
- Lewis B. Holmes, Boston, MA, USA
Submitted September 07, 2012 - Are newer antiepileptics really safer?
- Amit Maheshwari, senior resident neurology, SAIMS Indore Indianaman_amit@yahoo.com
- Amit Maheshwari,Sunil Athale,O.P.Lekhra,Kapil Telang-all Indore India
Submitted August 28, 2012
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