Is the development of late-life cognitive impairment more dynamic than sexy?
Citation Manager Formats
Make Comment
See Comments

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
As people age, they experience characteristic, generally subtle, changes in almost all bodily functions, including brain function.1 Psychomotor speed slows detectably across the adult lifespan.2 By age 50, many people have noticed that their memory is not as good as it was when they were younger; if it troubles them enough to seek medical evaluation, they are said to have a subjective memory complaint. Many people with a subjective memory complaint have cognitive test score abnormalities, often at a rate higher than those who are not troubled by their memory3; of these, many go on to develop dementia.
The evaluation of people with cognitive impairment who do not meet the criteria for dementia is an area of intense investigation. No group has contributed more than the Mayo Clinic investigators. They have reified criteria for mild cognitive impairment (MCI), and identified subtypes. People with MCI can be found with and without a predominant amnestic component, and further with and without impairment in other cognitive domains. Some subsequent epidemiologic reports appeared to contradict some of the initial estimates of the risk conferred by MCI. As Roberts et al.4 point out in this issue of Neurology®, discrepant estimates could be traced to many causes, epidemiologic studies sampling a different group than did …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hemiplegic Migraine Associated With PRRT2 Variations A Clinical and Genetic Study
Dr. Robert Shapiro and Dr. Amynah Pradhan