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February 28, 2012; 78 (9) Articles

Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging

Z.S. Tan, W.S. Harris, A.S. Beiser, R. Au, J.J. Himali, S. Debette, A. Pikula, C. DeCarli, P.A. Wolf, R.S. Vasan, S.J. Robins, S. Seshadri
First published February 27, 2012, DOI: https://doi.org/10.1212/WNL.0b013e318249f6a9
Z.S. Tan
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W.S. Harris
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A.S. Beiser
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R. Au
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J.J. Himali
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S. Debette
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A. Pikula
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C. DeCarli
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P.A. Wolf
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Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging
Z.S. Tan, W.S. Harris, A.S. Beiser, R. Au, J.J. Himali, S. Debette, A. Pikula, C. DeCarli, P.A. Wolf, R.S. Vasan, S.J. Robins, S. Seshadri
Neurology Feb 2012, 78 (9) 658-664; DOI: 10.1212/WNL.0b013e318249f6a9

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Article Information

vol. 78 no. 9 658-664
DOI: 
https://doi.org/10.1212/WNL.0b013e318249f6a9
PubMed: 
22371413

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 16, 2011
  • Accepted October 26, 2011
  • First Published February 27, 2012.

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. Z.S. Tan, MD, MPH,
    2. W.S. Harris, PhD,
    3. A.S. Beiser, PhD,
    4. R. Au, PhD,
    5. J.J. Himali, MS,
    6. S. Debette, MD,
    7. A. Pikula, MD,
    8. C. DeCarli, MD,
    9. P.A. Wolf, MD,
    10. R.S. Vasan, MD,
    11. S.J. Robins, MD and
    12. S. Seshadri, MD
  1. Z.S. Tan, MD, MPH,
  2. W.S. Harris, PhD,
  3. A.S. Beiser, PhD,
  4. R. Au, PhD,
  5. J.J. Himali, MS,
  6. S. Debette, MD,
  7. A. Pikula, MD,
  8. C. DeCarli, MD,
  9. P.A. Wolf, MD,
  10. R.S. Vasan, MD,
  11. S.J. Robins, MD and
  12. S. Seshadri, MD
  1. From the Department of Medicine, Division of Geriatric Medicine, and the Easton Center for Alzheimer's Disease Research (Z.S.T.), David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles; Cardiovascular Health Research Center (W.S.H.), Sanford Research, University of South Dakota, Sioux Falls; Department of Biostatistics (A.S.B., J.J.H.), Boston University School of Public Health, Boston; Departments of Neurology (A.S.B., J.J.H., S.S., R.A., S.D., A.P., P.A.W.) and Medicine (RSV, SR), Boston University School of Medicine, Boston, MA; Department of Neurology (C.D.), University of California-Davis, Davis; and the Framingham Heart Study (Z.S.T., A.S.B., R.A., P.A.W., R.S.V., S.J.R., S.S.), Framingham, MA.
  1. Correspondence & reprint requests to Dr. Tan: ztan{at}mednet.ucla.edu
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  • Omega-3 fatty acids such as docosahexaenoic acid activate retinoid X receptor pathways inducing ApoE expression and clearance of Beta-Amyloid with improved cognitive performance and inhibition of brain aging.
    • Steven R. Brenner, Staff physician, St. Louis University Dept. of Neurology and PsychiatrySBren20979@aol.com
    • St. Louis, MO
    Submitted March 16, 2012
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