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September 04, 2012; 79 (10) Articles

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers

Avner Thaler, Anat Mirelman, Tanya Gurevich, Ely Simon, Avi Orr-Urtreger, Karen Marder, Susan Bressman, Nir Giladi
First published August 22, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182684646
Avner Thaler
From the Movement Disorders Unit, Department of Neurology (A.T., A.M., T.G., N.G.) and Genetic Institute (A.O.-U.), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine (A.T., T.G., A.O.-U., N.G.), Tel Aviv University, Tel Aviv, Israel; School for Health Professions (A.M.), Ben-Gurion University, Beer Sheba, Israel; Department of Clinical Science (E.S.), NeuroTrax Corporation, Bellaire, Texas; Department of Neurology (E.S.), Albert Einstein College of Medicine, Bronx, New York; Columbia University (K.M.), Columbia Presbyterian Medical Center, New York, New York; and Beth Israel Medical Center (S.B.), New York, New York.
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Anat Mirelman
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Tanya Gurevich
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Ely Simon
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Susan Bressman
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Citation
Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
Avner Thaler, Anat Mirelman, Tanya Gurevich, Ely Simon, Avi Orr-Urtreger, Karen Marder, Susan Bressman, Nir Giladi
Neurology Sep 2012, 79 (10) 1027-1032; DOI: 10.1212/WNL.0b013e3182684646

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Abstract

Objective: To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene.

Methods: In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 ± 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale.

Results: G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007).

Conclusion: Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD.

GLOSSARY

AJ=
Ashkenazi Jewish;
EF=
executive function;
GDS=
Geriatric Depression Scale;
MoCA=
Montreal Cognitive Assessment test;
PD=
Parkinson disease;
RT=
reaction time;
UPDRS=
Unified Parkinson's Disease Rating Scale

Footnotes

  • LRRK2 Ashkenazi Jewish Consortium coinvestigators are listed on the Neurology® Web site at www.neurology.org.

  • Study funding: Supported by grants from the Tel Aviv Sourasky Medical Center Grant of Excellence, Khan Foundation, Israel Science Foundation Heritage Legacy, the Michael J. Fox Foundation for Parkinson's Research, and the UMC ST Radboud, Nijmegen, the Netherlands. The LRRK2 Ashkenazi Jewish Consortium is funded by the Michael J. Fox Foundation, New York, New York.

  • Supplemental data at www.neurology.org

  • This work was performed in partial fulfillment of the requirements of a PhD degree of Avner Thaler, Sackler Faculty of Medicine, Tel Aviv University, Israel.

  • Received December 9, 2011.
  • Accepted April 19, 2012.
  • Copyright © 2012 by AAN Enterprises, Inc.
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