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October 02, 2012; 79 (14) Articles

Poststroke fatigue following minor infarcts

A prospective study

Narges Radman, Fabienne Staub, Tatiana Aboulafia-Brakha, Alexandre Berney, Julien Bogousslavsky, Jean-Marie Annoni
First published September 5, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31826d5f3a
Narges Radman
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Fabienne Staub
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Tatiana Aboulafia-Brakha
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Alexandre Berney
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Julien Bogousslavsky
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Jean-Marie Annoni
From the Department of Neurology (N.R., J.-M.A.), University of Fribourg, Fribourg; Department of Neurology (F.S., T.A.-B., J.-M.A.) and Psychiatry Liaison Service (A.B.), Lausanne University Hospital, Lausanne; and Center for Brain and Nervous System Disorders (Neurocenter) (J.B.), Genolier, Switzerland.
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Citation
Poststroke fatigue following minor infarcts
A prospective study
Narges Radman, Fabienne Staub, Tatiana Aboulafia-Brakha, Alexandre Berney, Julien Bogousslavsky, Jean-Marie Annoni
Neurology Oct 2012, 79 (14) 1422-1427; DOI: 10.1212/WNL.0b013e31826d5f3a

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Abstract

Objective: To explore the potential relationship between fatigue following strokes and poststroke mood, cognitive dysfunction, disability, and infarct site and to determine the predictive factors in the development of poststroke fatigue (PSF) following minor infarcts.

Methods: Ninety-nine functionally active patients aged less than 70 years with a first, nondisabling stroke (NIH Stroke Scale score ≤6 in acute phase and ≤3 after 6 months, modified Rankin Scale score ≤1 at 6 months) were assessed during the acute phase and then at 6 (T1) and 12 months (T2) after their stroke. Scores in the Fatigue Assessment Inventory were described and correlated to age, gender, neurologic and functional impairment, lesion site, mood scores, neuropsychological data, laboratory data, and quality of life at T1 and T2 using a multivariate logistic regression analysis in order to determine which variables recorded at T1 best predicted fatigue at T2.

Result: As many as 30.5% of the patients at T1 and 34.7% at T2 (11.6% new cases between T1 and T2) reported fatigue. At both 6 and 12 months, there was a significant association between fatigue and a reduction in professional activity. Attentional-executive impairment, depression, and anxiety levels remained associated with PSF throughout this time period, underlining the critical role of these variables in the genesis of PSF. There was no significant association between the lesion site and PSF.

Conclusion: This study suggests that attentional and executive impairment, as well as depression and anxiety, may play a critical role in the development of PSF.

GLOSSARY

ACTH =
adrenocorticotropic hormone;
DSM-IV =
Diagnostic and Statistical Manual of Mental Disorders, 4th edition;
FAI =
Fatigue Assessment Instrument;
HARS =
Hamilton Anxiety Rating Scale;
HDRS =
Hamilton Depression Rating Scale;
MS =
multiple sclerosis;
NIHSS =
NIH Stroke Scale;
PSF =
poststroke fatigue;
TSH =
thyroid-stimulating hormone

Footnotes

  • Study funding: Supported by the Swiss National Science Foundation (32–138497 and 3200–061342).

  • Editorial, page 1414

  • Supplemental data at www.neurology.org

  • Received January 14, 2012.
  • Accepted May 1, 2012.
  • Copyright © 2012 by AAN Enterprises, Inc.
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