Skip to main content
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

October 02, 2012; 79 (14) Articles

Neurologic complications of influenza A(H1N1)pdm09

Surveillance in 6 pediatric hospitals

Gulam Khandaker, Yvonne Zurynski, Jim Buttery, Helen Marshall, Peter C. Richmond, Russell C. Dale, Jenny Royle, Michael Gold, Tom Snelling, Bruce Whitehead, Cheryl Jones, Leon Heron, Mary McCaskill, Kristine Macartney, Elizabeth J. Elliott, Robert Booy
First published September 19, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31826d5ea7
Gulam Khandaker
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yvonne Zurynski
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Buttery
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helen Marshall
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter C. Richmond
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Russell C. Dale
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jenny Royle
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Gold
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tom Snelling
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruce Whitehead
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cheryl Jones
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leon Heron
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary McCaskill
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristine Macartney
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth J. Elliott
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Booy
From the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (G.K., T.S., L.H., K.M., R.B.), Sydney; The Discipline of Paediatrics and Child Health (G.K., Y.Z., R.C.D., C.J., L.H., K.M., E.J.E., R.B.), The University of Sydney, Sydney; The Australian Paediatric Surveillance Unit (Y.Z., E.J.E.), Sydney; Murdoch Children's Research Institute (J.B., J.R.), and Immunisation Service, Department of General Medicine, Royal Children's Hospital, Melbourne; Department of Paediatrics (J.B.), Monash University, Melbourne; Vaccinology and Immunology Research Trials Unit (H.M.), Women's and Children's Hospital, Adelaide, South Australia; School of Paediatrics and Reproductive Health (H.M., M.G.), University of Adelaide, South Australia; School of Paediatrics and Child Health (P.C.R.), University of Western Australia, Perth; Sydney Children's Hospital (T.S.), Randwick; Respiratory Medicine (B.W.), John Hunter Children's Hospital, New South Wales; Department of Emergency Medicine (M.M.), The Children's Hospital at Westmead, Sydney; and The Sydney Institute for Emerging Infections and Biosecurity (SEIB) (C.J., L.H., K.M., E.J.E., R.B.), Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Neurologic complications of influenza A(H1N1)pdm09
Surveillance in 6 pediatric hospitals
Gulam Khandaker, Yvonne Zurynski, Jim Buttery, Helen Marshall, Peter C. Richmond, Russell C. Dale, Jenny Royle, Michael Gold, Tom Snelling, Bruce Whitehead, Cheryl Jones, Leon Heron, Mary McCaskill, Kristine Macartney, Elizabeth J. Elliott, Robert Booy
Neurology Oct 2012, 79 (14) 1474-1481; DOI: 10.1212/WNL.0b013e31826d5ea7

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
663

Share

  • Article
  • Figures & Data
  • Info & Disclosures
  • CME Course
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1′09) in children hospitalized with influenza.

Methods: Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, for children aged <15 years with laboratory-confirmed pH1N1′09.

Results: A total of 506 children with pH1N1′09 were hospitalized, of whom 49 (9.7%) had neurologic complications; median age 4.8 years (range 0.5–12.6 years) compared with 3.7 years (0.01–14.9 years) in those without complications. Approximately one-half (55.1%) of the children with neurologic complications had preexisting medical conditions, and 42.8% had preexisting neurologic conditions. On presentation, only 36.7% had the triad of cough, fever, and coryza/runny nose, whereas 38.7% had only 1 or no respiratory symptoms. Seizure was the most common neurologic complication (7.5%). Others included encephalitis/encephalopathy (1.4%), confusion/disorientation (1.0%), loss of consciousness (1.0%), and paralysis/Guillain-Barré syndrome (0.4%). A total of 30.6% needed intensive care unit (ICU) admission, 24.5% required mechanical ventilation, and 2 (4.1%) died. The mean length of stay in hospital was 6.5 days (median 3 days) and mean ICU stay was 4.4 days (median 1.5 days).

Conclusions: Neurologic complications are relatively common among children admitted with influenza, and can be life-threatening. The lack of specific treatment for influenza-related neurologic complications underlines the importance of early diagnosis, use of antivirals, and universal influenza vaccination in children. Clinicians should consider influenza in children with neurologic symptoms even with a paucity of respiratory symptoms.

GLOSSARY

APSU=
Australian Pediatric Surveillance Unit;
CHW=
Children's Hospital at Westmead;
CI=
confidence interval;
EL=
encephalitis lethargica;
GBS=
Guillain-Barré syndrome;
HAPS=
Hunter Area Pathology Service;
ICU=
intensive care unit;
ILAE=
International League Against Epilepsy;
ILI=
influenza-like illness;
JHCH=
John Hunter Children's Hospital;
LOS=
length of stay;
NCIRS=
National Centre for Immunization Research and Surveillance;
PAEDS=
Pediatric Active Enhanced Disease Surveillance;
PMH=
Princes Margaret Hospital Perth;
RCH=
Royal Children's Hospital Melbourne;
SCH=
Sydney Children's Hospital;
SEALS=
South Eastern Area Laboratory Service;
VIDRL=
Victorian Infectious Diseases Reference Laboratory;
WCH=
Women's and Children's Hospital Adelaide.

Footnotes

  • Supplemental data at www.neurology.org

  • Received September 24, 2011.
  • Accepted April 19, 2012.
  • Copyright © 2012 by AAN Enterprises, Inc.
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
  • CME Course

More Online

CME Course

SARS-CoV-2 Vaccination Safety in Guillain-Barré Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy

Dr. Jeffrey Allen and Dr. Nicholas Purcell

► Watch

Topics Discussed

  • All Pediatric
  • All Infections
  • All epidemiology
  • Viral infections

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Editorial
    Influenza vaccines and Guillain-Barré syndrome
    The continuing question
    James J. Sejvar et al.
    Neurology, October 28, 2013
  • Null Hypothesis
    Seasonal influenza vaccine and Guillain-Barré syndrome
    A self-controlled case series study
    Clémence Grave, Pauline Boucheron, Jérémie Rudant et al.
    Neurology, February 25, 2020
  • Article
    Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States
    Jonathan Duffy, Eric Weintraub, Claudia Vellozzi et al.
    Neurology, October 15, 2014
  • Research
    Uptake and Attitudes About Immunizations in People With Multiple Sclerosis
    Ruth Ann Marrie, Leanne Kosowan, Gary R. Cutter et al.
    Neurology: Clinical Practice, April 22, 2021
Neurology: 100 (12)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise