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October 09, 2012; 79 (15) Articles

Emotional neglect in childhood and cerebral infarction in older age

Robert S. Wilson, Patricia A. Boyle, Steven R. Levine, Lei Yu, Sophia E. Anagnos, Aron S. Buchman, Julie A. Schneider, David A. Bennett
First published September 19, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31826e25bd
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Article Information

vol. 79 no. 15 1534-1539
DOI: 
https://doi.org/10.1212/WNL.0b013e31826e25bd
PubMed: 
22993291
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 14, 2011
  • Accepted April 10, 2012
  • First Published September 19, 2012.

Article Versions

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. Robert S. Wilson, PhD,
    2. Patricia A. Boyle, PhD,
    3. Steven R. Levine, MD,
    4. Lei Yu, PhD,
    5. Sophia E. Anagnos, BA,
    6. Aron S. Buchman, MD,
    7. Julie A. Schneider, MD and
    8. David A. Bennett, MD
  1. Robert S. Wilson, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Aging, Neuropsychology, and Cognition, Consulting Editor, 2004-present; Psychology and Aging, Consulting Editor, 2007-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Pain Therapeutics, Inc.

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIA R01AG024871, PI, 2006-2011; NIH/NIA P30AG10161, Co-I, 1991-2011; NIH/NIA R01AG11101, Co-I, 1993-2011; NIH/NIA R01AG15819, Co-I, 1998-2013

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Patricia A. Boyle, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIA R01AG034374, PI; NIH/NIA R01AG033678, PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Steven R. Levine, MD,
    4. Scientific Advisory Boards:

    1. Independent Medical/Safety Monitor for NINDS-funded IMS 3, INSTINCT, and CLEAR-ER; Adjudication committee for NINDS-funded WARCEF

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Genentech-sponsored investigator meeting - travel expenses reimbursement in 2010, 2011

    Editorial Boards:

    1. MEDLINK, Associate Editor, 1996-present; National Stroke Association, scientific content advisor, 2010, 2011

    Patents:

    1. NONE

    Publishing Royalties:

    1. Book: Transient Ischemic Attacks, Blackwell Futura, 2004

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Genentech-sponsored investigator meeting - consultant, 2010; Genentech study on cost-effectiveness of primary stroke centers, 2011 - consultant within a study group Speakers’ Bureaus:; Medical Education Speakers Network, lecturer, 2008-2011; NCME, lecturer, 2008-2011

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH-NHLBI 1R01 HL096944, principal investigator, 2009- 2013; NIH-NINDS 1UO1 NS044364, Independent safety monitor, 2003 - 2012; NIH-NINDS 1 U10 NS077378,PI, 2011 - 2017 Non-financial disclosures: AAN Working Group for Telemedicine and Neurology Course Director for Telestroke for the Annual AAN meeting, 2008-2011

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Lei Yu, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Sophia E. Anagnos, BA,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA, P30AG010161, Research Assistant; NIA, R01AG017917, Research Assistant

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Aron S. Buchman, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH R01AG17917, co-I, 2001-13; NIH R01AG24480, PI, 2005-12

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Julie A. Schneider, MD and
    8. Scientific Advisory Boards:

    1. 1. served on scientific advisory board for GE Healthcare; 2. served on scientific advisory board for Eli Lilly and Company;

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 2005-current Journal Histochemistry and Cytochemistry (Monitoring editor) 2008-current International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) (Editorial Board) 2010 Journal of Alzheimer’s Disease (Associate Editor)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Neuropathology consultant, AVID radiopharmaceuticals 2009-12

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. AVID radiopharmaceutical phase III clinical trial Neuropathologist 2010-2011

    Research Support, Government Entities:

    1. P30 AG10161 (Bennett)9/30/91-6/30/11 Rush Alzheimer’s Disease Core Center; Major goals to provide core infrastructure support for research regarding aging/AD. Role: Core Leader: Neuropathology Core R01 AG031553 (Morris)3/15/08 –2/28/13 Epidemiologic Study of Brain Vitamin E, Diet, and Age- Related Neurologic Diseases; major goal is analyze Vitamin E in brain, CSF, serum, and diet and compare to neuropathology. Role: Co-Investigator R01 AG17917 (Bennett)9/30/01-6/30/13 Epidemiologic Study of Neural Reserve and Neurobiology of Aging; Major goals are to identify structural bases of reserve and examine mechanisms risk factors lead to age- related functional impairment.Role:Co-Investigator R01 AG024480 (Buchman)7/1/05 –6/30/10 Risk Factors and the Neurobiologic Substrate of Frailty; Major goals of this project are to identify the neurobiologic substrate of physical frailty and identify risk factors for frailty. Role: Co-Investigator R01 AG15819 (Bennett) 7/1/98 –6/30/13 Risk Factors, Pathology and Clinical Expressions of AD The major goals of this project are to examine the pathologic mechanisms through which risk factors lead to clinical AD. Role: Co-investigator P01 AG14449 (Mufson)9/1/97 –3/31/13 Neurobiology of Mild cognitive impairment in the Elderly;The major goals are to identify neurobiologic substrates of mild cognitive impairment. Role: Co-investigator (Neuropathologist) P01 AG09466 (deToledo-Morrell)4/1/1991-8/31/10 Anatomic, Physiologic, Cognitive Pathology of AD; Major goals to identify neurobiologic, radiologic, physiologic, cognitive markers of AD Role: Co-Investigator; Neuropathologist, Administrative Core R01 AG24871 (Wilson)7/1/06 –4/30/11 Neurobiologic Study of Psychological Distress & Dementia; Major goal to identify the mechanisms underlying the association of chronic psychological distress with dementia. Role: Co-investigator (Neuropathologist) R21 AG30765 (Bennett)9/1/07 –6/30/10 Degraded Rationality: Subclinical Neuropathology and Neuroeconomic Behavior in Older Persons Role: Co-Investigator R21 AG030346 (Kelly)9/30/08 –8/31/10 Relationship Between AD Clinicopathological Changes and CNS Sex Steroid Hormones; Major goal is to determine the relationship between brain tissue hormone levels and cognitive impairment, and AD pathology. Role: Neuropathologist R01AG033678-01(Boyle)9/15/2009 - 6/30/14 Epidemiologic study of Impaired decision making in preclinical Alzheimer’s disease. The overall goal of the proposed epidemiologic study is to examine the causes and consequences of impaired decision-making in old age. Role: Neuropathologist R01AG034374 (Boyle)8/15/2009 -7/31/14 Characterizing the behavior profile of healthy cognitive aging. Goal is to use innovative statistical approaches to characterize the profile of healthy cognitive aging defined as age-related cognitive change not accounted for by the presence of common neuropathologies (i.e., Alzheimer’s disease, cerebral infarcts, and the Lewy body diseases) or terminal decline. Role: Neuropathologist.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. David A. Bennett, MD
    9. Scientific Advisory Boards:

    1. Vigorous Minds, Scientific Advisory Board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology, Editorial Board; Current Alzheimer Research, Editorial Board; Neuroepidemiology, Editorial Board; Frontiers Neurology, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Danone, Inc.; Wilmar Schwabe GmbH & Co.; Eli Lilly, Inc.; the Gerson Lehrman Group

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Danone Inc., PI

    Research Support, Government Entities:

    1. NIH R01AG017917, PI; NIH R01AG015819, PI; NIH R01AG036042, PI; NIH RC2AG036547, PI; NIH U01AG032984, Co-PI, Leader of Epidemiologic Cohort Studies; NIH R01AG024480, Co-I; NIH R01AG024871, Co-I; NIH P01AG009466, Co-I; NIH U24AG026395, Co- I; NIH R01AG030142, Co-I; NIH P01AG01449, Co-I; NIH R01HL096944, Co-I; NIH R01AG033678, Co-I; NIH R01AG034374, Co-I; NIH R01AG032755, Co-I; NIH P30AG010161, PI-Administrative core leader, Religious Orders Study core leader; Illinois Department Public Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Rush Alzheimer's Disease Center (R.S.W., P.A.B., L.Y., S.E.A., A.S.B., J.A.S., D.A.B.) and Departments of Neurological Sciences (R.S.W., L.Y., A.S.B., J.A.S., D.A.B.), Behavioral Sciences (R.S.W., P.A.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; and Departments of Neurology and Emergency Medicine (S.R.L.), SUNY Downstate Medical Center, Brooklyn, NY.
  1. Correspondence & reprint requests to Dr. Wilson: rwilson{at}rush.edu.
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