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October 16, 2012; 79 (16) Editorials

Breaking down barriers to identify hemorrhagic transformation in ischemic stroke

Glen C. Jickling, Bogdan N. Manolescu
First published September 19, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31826e9b9d
Glen C. Jickling
From the Department of Neurology and the MIND Institute (G.C.J.), University of California at Davis, Sacramento; and Department of Organic Chemistry “C. Neniescu” (B.N.M.), Faculty of Applied Chemistry and Science of Materials, Polytechnic University of Bucharest, Bucharest, Romania.
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Bogdan N. Manolescu
From the Department of Neurology and the MIND Institute (G.C.J.), University of California at Davis, Sacramento; and Department of Organic Chemistry “C. Neniescu” (B.N.M.), Faculty of Applied Chemistry and Science of Materials, Polytechnic University of Bucharest, Bucharest, Romania.
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Breaking down barriers to identify hemorrhagic transformation in ischemic stroke
Glen C. Jickling, Bogdan N. Manolescu
Neurology Oct 2012, 79 (16) 1632-1633; DOI: 10.1212/WNL.0b013e31826e9b9d

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Hemorrhagic transformation (HT) is a major complication in ischemic stroke, associated with increased morbidity and mortality. Identifying ischemic stroke patients at risk of HT could have substantial clinical implications, especially in the setting of thrombolytic therapy. Acute stroke patients at very high risk for HT could foreseeably have alternative treatment, such as a modified dose of thrombolytic agent or coadministration of a second agent able to reduce HT risk.

In this issue of Neurology®, Kazmierski et al.1 sought to predict clinical deterioration due to HT in ischemic stroke by measurements of proteins in blood. A total of 458 stroke patients were enrolled in their study, 85 of whom experienced clinical deterioration, and 33 of whom had HT. Stroke patients who developed HT had increased fasting glucose and decreased platelet count compared to those …

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