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October 30, 2012; 79 (18) Articles

Hormone therapy and Alzheimer disease dementia

New findings from the Cache County Study

Huibo Shao, John C.S. Breitner, Rachel A. Whitmer, Junmin Wang, Kathleen Hayden, Heidi Wengreen, Chris Corcoran, JoAnn Tschanz, Maria Norton, Ron Munger, Kathleen Welsh-Bohmer, Peter P. Zandi
First published October 24, 2012, DOI: https://doi.org/10.1212/WNL.0b013e318271f823
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Article Information

vol. 79 no. 18 1846-1852
DOI: 
https://doi.org/10.1212/WNL.0b013e318271f823
PubMed: 
23100399
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 22, 2012
  • Accepted June 11, 2012
  • First Published October 24, 2012.

Article Versions

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. Huibo Shao, MS,
    2. John C.S. Breitner, MD,
    3. Rachel A. Whitmer, PhD,
    4. Junmin Wang, PhD,
    5. Kathleen Hayden, PhD,
    6. Heidi Wengreen, PhD,
    7. Chris Corcoran, PhD,
    8. JoAnn Tschanz, PhD,
    9. Maria Norton, PhD,
    10. Ron Munger, PhD,
    11. Kathleen Welsh-Bohmer, PhD and
    12. Peter P. Zandi, PhD
    13. For the Cache County Investigators
  1. Huibo Shao, MS,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. John C.S. Breitner, MD,
    3. Scientific Advisory Boards:

    1. N. Bud Grossman Center for Research in Memory and Care, Minneapolis, MN member, Scientific Advisory Board, appointed 2009 Florida ADRC (NIA and State of FL), Scientific Advisory Board, 2006 - 2008 Chicago Health and Aging Project, Scientific Advisory Board, 2009 Data and Safety Monitoring Board, SPRINT-MIND clinical trial (NIA / NHLBI sponsor) Minimial compensation for episodic service as ad hoc reviewer for NIH intramural and extramural programs.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Receive rare honoraria for industry-sponsored talks

    Editorial Boards:

    1. Alzheimer’s Disease and Associated Disorders, Editorial Board, 2003 - present; PLOS-One, Academics, 2009 - present; Alzheimer’s and Dementia, Editorial Board, 2007 - present; American Journal of Alzheimers’ Disease, 1997 - present

    Patents:

    1. NONE

    Publishing Royalties:

    1. Fast Facts - Dementia. Second Edition. Health Press, 2009

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institute on Aging, U01-AG-15477, PI, 2000 - present; Minnesota Medical Foundation, PI, 2009 - present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Rachel A. Whitmer, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Junmin Wang, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kathleen Hayden, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Alzheimer’s & Dementia, Senior Editor 2007-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH, R01-AG1380 NIH, K01-AG029336 NIH, P30-AG028377

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Heidi Wengreen, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH, R155AG037392-01, PI, 2010-2013.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Chris Corcoran, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIEHS, R01 ES 016669, Co-Investigator (Biostatistician), 2010-2015; NIH/NCBDD, U01 DD 000698, Co-Investigator (Biostatistician), 2010-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. JoAnn Tschanz, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Building Interdisciplinary Research Careers in Women’s Health, non- profit, speaker honorarium

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA/R01AG21136, PI, 2002 to present

    Research Support, Academic Entities:

    1. Utah State University

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Maria Norton, PhD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH AG-11380, Project manager, 1994-2001; NIH AG-11380, Subcontract PI, 2002-present; NIH AG-18712, Co-investigator, 2000-2005; NIH AG-211386, Co-investigator, 2002-present; NIH AG-31272, Principal Investigator, 2008-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Ron Munger, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. U.S. National Institutes of Health 1 R01 AG21136 Role: co-investigator Years: 2008-2012 Title: Progression of Dementia: A Population Study This study investigates the clinical course of dementia and the genetic and environmental factors which effect cognitive, behavioral, and functional decline.

    Research Support, Academic Entities:

    1. Utah State University, faculty appointment and salary

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Kathleen Welsh-Bohmer, PhD and
    12. Scientific Advisory Boards:

    1. 1) Zinfandel Pharmaceuticals; ; 2) Takeda Phamaceuticals;

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 1) Takeda: travel to consulting meetings

    Editorial Boards:

    1. Alzheimer’s & Dementia, Editorial Advisory Board, 2005-present; Journal International Neuropsychological Society, Editorial Board, 1999-present; Aging, Neuropsychology, and Cognition, Consulting Editor, 1999-present; Neuropsychology, Consulting Editor, 1992-present

    Patents:

    1. Use patent, April 28, 1999 filed; Feb 23, 2005 issued; Patent #6867236; Appl #09/300,789

    Publishing Royalties:

    1. Geriatric Neuropsychology: Assessment and Intervention. Deborah K. Attix & Kathleen A. Welsh-Bohmer (Eds). Guildford Publications: New York, 2006.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Zinfandel and Takeda Pharmaceutical companies

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Contract support to Bryan ADRC from Zinfandel/Takeda pharmaceutical companies

    Research Support, Government Entities:

    1. NIA, AG11380, PI of study, 2002-2011; NIA, AG028377, PI of study, 2006-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Peter P. Zandi, PhD
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIMH; K01 MH072866-01; Primary Investigator; 02/01/05 – 01/31/11 NIMH; R01 MH083738-01; Primary Investigator; 12/01/09 – 11/30/12 NIA; BJ18-JHU-ARRA; Primary Investigator (sub-contract); 09/01/09 – 07/31/10 NIH; R01MH076953; Co-Investigator; 01/25/07 – 12/31/11 NIH; R37AA12303; Co-Investigator; 07/01/99 – 07/31/10 NIH; R01MH079240; Co-Investigator; 09/11/07 – 05/31/11 NIMH; K99MH086049 - 01A1; Co-mentor; 12/1/09-11/30/14 NIH; R37DA011796; Co-Investigator; 07/01/09 – 04/30/14 NIA; R0I AG 11380; Co-Investigator; 07/01/2002 – 06/30/2007 NIMH; R0I MH 47447; Co-Investigator; 07/01/2002 – 06/30/2007 NIMH; RO1 MH59533; Co-Investigator; 12/01/2003-11/30/2007 NIMH; R01 MH 42243; Co-Investigator; 04/01/2005 – 03/31/2010 NAAR; Primary Investigator; 11/01/2003-10/31/2005 NARSAD; Co-Investigator; 05/01/2003-04/30/2005 NARSAD; Primary Investigator; 07/01/2004-10/31/2006

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

                                                              1. From the Department of Public Health (H.S.), Weill Cornell Medical College, New York, NY; Department of Psychiatry (J.C.S.B.), McGill University Faculty of Medicine, Montreal, Canada; Division of Research (R.A.W.), Kaiser Permanente Northern California, Oakland; Department of Sociology (J.W.), University of Memphis, Memphis, TN; Department of Psychiatry and Behavioral Sciences (K.H., K.W.-B.), Duke University School of Medicine, Durham, NC; Departments of Nutrition and Food Sciences (H.W.), Mathematics and Statistics (C.C.), Psychology (J.T.), and Family Consumer & Human Development (M.N.), and Center for Epidemiologic Studies (C.C., J.T., M.N., R.M.), Utah State University, Logan; and Department of Mental Health (P.P.Z.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
                                                              1. Michigan State University
                                                              1. Brigham Young University
                                                              1. UCLA
                                                              1. Duke University
                                                              1. Duke University
                                                              1. Duke University
                                                              1. Harvard University
                                                              1. Duke University
                                                              1. Duke University
                                                              1. Alzheimer's & Dementia
                                                              1. Utah State University
                                                              1. Utah State University
                                                              1. Johns Hopkins University
                                                              1. Washington University in Saint Louis
                                                              1. Johns Hopkins University
                                                              1. Duke University
                                                              1. Mayo Clinic
                                                              1. Utah State University
                                                              1. Duke University
                                                              1. Duke University
                                                              1. Johns Hopkins University
                                                              1. Duke University
                                                              1. University of Gothenburg
                                                              1. Duke University
                                                              1. Johns Hopkins University
                                                              1. Utah State University
                                                              1. Utah State University
                                                              1. University of Utah
                                                              1. Duke University
                                                              1. Utah State University
                                                              1. Correspondence & reprint requests to Dr. Zandi: pzandi{at}jhsph.edu
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