Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

November 06, 2012; 79 (19) Articles

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

Debby Tsuang, James B. Leverenz, Oscar L. Lopez, Ronald L. Hamilton, David A. Bennett, Julie A. Schneider, Aron S. Buchman, Eric B. Larson, Paul K. Crane, Jeffrey A. Kaye, Patricia Kramer, Randy Woltjer, Walter Kukull, Peter T. Nelson, Gregory A. Jicha, Janna H. Neltner, Doug Galasko, Eliezer Masliah, John Q. Trojanowski, Gerard D. Schellenberg, Dora Yearout, Haley Huston, Allison Fritts-Penniman, Ignacio F. Mata, Jia Y. Wan, Karen L. Edwards, Thomas J. Montine, Cyrus P. Zabetian
First published October 3, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182735e9a
Debby Tsuang
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James B. Leverenz
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oscar L. Lopez
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ronald L. Hamilton
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Bennett
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julie A. Schneider
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aron S. Buchman
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric B. Larson
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul K. Crane
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey A. Kaye
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patricia Kramer
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Randy Woltjer
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter Kukull
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter T. Nelson
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory A. Jicha
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janna H. Neltner
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Doug Galasko
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eliezer Masliah
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Q. Trojanowski
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerard D. Schellenberg
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dora Yearout
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haley Huston
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Allison Fritts-Penniman
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ignacio F. Mata
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jia Y. Wan
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karen L. Edwards
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas J. Montine
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cyrus P. Zabetian
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology
Debby Tsuang, James B. Leverenz, Oscar L. Lopez, Ronald L. Hamilton, David A. Bennett, Julie A. Schneider, Aron S. Buchman, Eric B. Larson, Paul K. Crane, Jeffrey A. Kaye, Patricia Kramer, Randy Woltjer, Walter Kukull, Peter T. Nelson, Gregory A. Jicha, Janna H. Neltner, Doug Galasko, Eliezer Masliah, John Q. Trojanowski, Gerard D. Schellenberg, Dora Yearout, Haley Huston, Allison Fritts-Penniman, Ignacio F. Mata, Jia Y. Wan, Karen L. Edwards, Thomas J. Montine, Cyrus P. Zabetian
Neurology Nov 2012, 79 (19) 1944-1950; DOI: 10.1212/WNL.0b013e3182735e9a

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
1064

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objectives: Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzheimer disease (AD) neuropathologic changes (ADNCs), or both.

Methods: We screened the entire GBA coding region for mutations in controls and in subjects with dementia and LBDNCs and no or low levels of ADNCs (pure dementia with Lewy bodies [pDLB]), LBDNCs and high-level ADNCs (LBD-AD), and high-level ADNCs but without LBDNCs (AD).

Results: Among white subjects, pathogenic GBA mutations were identified in 6 of 79 pDLB cases (7.6%), 8 of 222 LBD-AD cases (3.6%), 2 of 243 AD cases (0.8%), and 3 of 381 controls (0.8%). Subjects with pDLB and LBD-AD were more likely to carry mutations than controls (pDLB: odds ratio [OR] = 7.6; 95% confidence interval [CI] = 1.8–31.9; p = 0.006; LBD-AD: OR = 4.6; CI = 1.2–17.6; p = 0.025), but there was no significant difference in frequencies between the AD and control groups (OR = 1.1; CI = 0.2–6.6; p = 0.92). There was a highly significant trend test across groups (χ2(1) = 19.3; p = 1.1 × 10−5), with the likelihood of carrying a GBA mutation increasing in the following direction: control/AD < LBD-AD < pDLB.

Conclusions: GBA is a susceptibility gene across the LBD spectrum, but not in AD, and appears to convey a higher risk for PD and pDLB than for LBD-AD. PD and pDLB might be more similar to one another in genetic determinants and pathophysiology than either disease is to LBD-AD.

GLOSSARY

AD=
Alzheimer disease;
ADC=
Alzheimer disease center;
ADNCs=
Alzheimer disease neuropathologic changes;
CI=
confidence interval;
DLB=
dementia with Lewy bodies;
LBD=
Lewy body disease;
LBDNCs=
Lewy body disease neuropathologic changes;
OR=
odds ratio;
PD=
Parkinson disease;
PDD=
Parkinson disease with dementia;
pDLB=
pure dementia with Lewy bodies

Footnotes

  • Study funding: Supported by grants from the Department of Veterans Affairs (1I01BX000531) and the National Institutes of Health (P30 AG008017, P30 AG028383, P30 AG010124, P30 AG010161, P50 AG005131, P50 NS062684, P50 AG005136, P50 AG005133, R01 AG007584, R01 AG010845, R01 AG015819, R01 AG017917, R01 NS048595, R01 NS065070, U01 AG006781, and U01 AG016976).

  • Editorial. page 1938

  • Supplemental data at www.neurology.org

  • Received April 30, 2012.
  • Accepted June 18, 2012.
  • Copyright © 2012 by AAN Enterprises, Inc.
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Effect of Atogepant for Preventive Migraine Treatment on Patient-Reported Outcomes in the Randomized, Double-blind, Phase 3 ADVANCE Trial

Dr. Jessica Ailani and Dr. Ailna Masters-Israilov

► Watch

Related Articles

  • “Untangling” the relationship between Alzheimer disease and dementia with Lewy bodies

Topics Discussed

  • Alzheimer's disease
  • Dementia with Lewy bodies
  • Association studies in genetics
  • Parkinson's disease/Parkinsonism

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Views & Reviews
    DLB and PDD boundary issues
    Diagnosis, treatment, molecular pathology, and biomarkers
    C. F. Lippa, J. E. Duda, M. Grossman et al.
    Neurology, March 12, 2007
  • Article
    Motion discrimination in dementia with Lewy bodies and Alzheimer disease
    Kelly M. Landy, David P. Salmon, Douglas Galasko et al.
    Neurology, September 23, 2015
  • Article
    Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease
    Julia Shirvan, Nathan Clement, Rong Ye et al.
    Neurology, June 26, 2019
  • Articles
    Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies
    Mona K. Beyer, Jan P. Larsen, Dag Aarsland et al.
    Neurology, August 20, 2007
Neurology: 100 (23)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise