Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

November 20, 2012; 79 (21) Article

Endothelial injury in childhood stroke with cerebral arteriopathy

A cross-sectional study

Despina Eleftheriou, Vijeya Ganesan, Ying Hong, Nigel J. Klein, Paul A. Brogan
First published October 17, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182752c7e
Despina Eleftheriou
From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vijeya Ganesan
From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Hong
From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nigel J. Klein
From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul A. Brogan
From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Endothelial injury in childhood stroke with cerebral arteriopathy
A cross-sectional study
Despina Eleftheriou, Vijeya Ganesan, Ying Hong, Nigel J. Klein, Paul A. Brogan
Neurology Nov 2012, 79 (21) 2089-2096; DOI: 10.1212/WNL.0b013e3182752c7e

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
366

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Article Information

vol. 79 no. 21 2089-2096
DOI: 
https://doi.org/10.1212/WNL.0b013e3182752c7e
PubMed: 
23077025

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 18, 2012
  • Accepted June 21, 2012
  • First Published October 17, 2012.

Article Versions

  • Previous version (October 17, 2012 - 13:02).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2012 American Academy of Neurology

Author Disclosures

    1. Despina Eleftheriou, MBBS,
    2. Vijeya Ganesan, MD,
    3. Ying Hong, PhD,
    4. Nigel J. Klein, PhD and
    5. Paul A. Brogan, PhD
  1. Despina Eleftheriou, MBBS,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Action medical research fellowship grant RTF 1355

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Vijeya Ganesan, MD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Developmental Medicine Child Neurology, Editorial Board, 2011-current

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Ying Hong, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Arthritis research UK and a National Institute for Health Research/Biomedical Research Centre project grant.

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Nigel J. Klein, PhD and
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Paul A. Brogan, PhD
  10. Scientific Advisory Boards:
    1. 1. Scientific advisor to Roche in relation to design of our clinical trial of rituximab in children with ANCA vasculitis 2011- 2012

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. 1. Payment/stipend and travel expenses from the American society of nephrology 2011 to give a talk at the annual ASN meeting, Philadelphia 2011

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. 1. Aspreva. A randomised clinical trial of mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA associated vasculitis in children 1/6/2008-30/9/2011 2. Wellcome Trust. The UK National Juvenile Dermatomyositis Cohort. 1/1/2009-31/12/2011 3. HEFCE. Clinical Senior Lecturer Fellowship. 1/3/2009-28/2/2014 4. Action Medical Research.Inflammation and endothelial injury in childhood central nervous system vasculitis: identifying biomarkers predictive of disease progression. PhD Fellowship for Dr D Eleftheriou. 1/8/09-31/7/2012 5. Arthritis Research UK. The vasculopathy of Juvenile dermatomyositis. 1/9/09-1/3/10 6. Nuffield Foundation Oliver Bird Rheumatism Programme. Homozygosity mapping for the discovery of novel autoinflammatory disease.1/09/2009-31/08/2012 7. Great Ormond St Hospital Children's Charity. Endothelial injury and repair in vasculitis of the young.1/10/2010-28/2/2011 8. Novartis: One year open-label multicentre trial to assess efficacy, safety and tolerability of canakinumab in patients aged four years or younger with cryopyrin associated periodic syndromes (CAPS). 1/4/2011-31/3/2012 9. Biomedical Research Centre NIHR grant. Neutrophil microparticles in the pathogenesis of ANCA associated vasculitis. 1/3/2011-1/8/2012 10. British Heart Foundation. Subclinical vasculitis, late vasculopathy and myocardial performance years after Kawasaki disease in the UK. 1/5/11-30/4/2013

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. 1. Expert legal witness in UK in the last two years.

  1. From the Paediatric Rheumatology Department (D.E., Y.H., P.A.B.), Neurosciences Unit (V.G.), and Infectious Diseases and Microbiology Unit (N.J.K.), Institute of Child Health and Great Ormond St Hospital for Children, London, UK.
  1. Correspondence & reprint requests to Dr. Eleftheriou: d.eleftheriou{at}ich.ucl.ac.uk
View Full Text

Article usage

Article usage: October 2012 to April 2022

AbstractFullPdfSource
Oct 2012393017Highwire
Nov 201214593788Highwire
Dec 20124152031Highwire
Jan 201318468Highwire
Feb 20135746Highwire
Mar 20138966Highwire
Apr 20136246Highwire
May 20133623Highwire
Jun 20133822Highwire
Jul 20131541Highwire
Aug 20133100Highwire
Sep 20132723Highwire
Oct 20133426Highwire
Nov 20132303Highwire
Dec 20132225Highwire
Jan 20142313Highwire
Jan 2014075pmc
Feb 20142562Highwire
Mar 20142222Highwire
Apr 20142020Highwire
May 20142611Highwire
Jun 20142810Highwire
Jul 20144610Highwire
Aug 20142700Highwire
Sep 20143824Highwire
Oct 20142331Highwire
Nov 20142122Highwire
Dec 20142720Highwire
Jan 20151834Highwire
Jan 20150128pmc
Feb 20151523Highwire
Feb 2015052pmc
Mar 20152402Highwire
Mar 2015073pmc
Apr 20151001Highwire
Apr 2015074pmc
May 20151501Highwire
May 2015098pmc
Jun 20151011Highwire
Jun 2015043pmc
Jul 20152111Highwire
Jul 2015062pmc
Aug 20152310Highwire
Aug 2015071pmc
Sep 20152000Highwire
Sep 20150104pmc
Oct 20151101Highwire
Oct 2015043pmc
Nov 20152123Highwire
Nov 2015065pmc
Dec 20152000Highwire
Dec 20150103pmc
Jan 20161510Highwire
Jan 2016077pmc
Feb 20161800Highwire
Feb 2016053pmc
Mar 2016901Highwire
Mar 2016073pmc
Apr 20161401Highwire
Apr 2016031pmc
May 20161600Highwire
May 2016074pmc
Jun 20161600Highwire
Jun 2016022pmc
Jul 20162400Highwire
Jul 2016061pmc
Aug 20162220Highwire
Aug 2016054pmc
Sep 20162000Highwire
Sep 2016063pmc
Oct 20161821Highwire
Oct 2016062pmc
Nov 20161700Highwire
Nov 2016071pmc
Dec 20162700Highwire
Dec 2016053pmc
Jan 20172120Highwire
Jan 2017033pmc
Feb 20171600Highwire
Feb 2017044pmc
Mar 20171201Highwire
Apr 20172200Highwire
Apr 2017011pmc
May 20171100Highwire
May 2017465pmc
Jun 2017400Highwire
Jun 2017244pmc
Jul 2017710Highwire
Jul 2017011pmc
Aug 2017810Highwire
Aug 2017254pmc
Sep 2017300Highwire
Sep 2017588pmc
Oct 20171000Highwire
Oct 2017022pmc
Nov 2017911Highwire
Nov 2017123pmc
Dec 2017200Highwire
Jan 2018900Highwire
Feb 2018300Highwire
Mar 2018900Highwire
Apr 2018701Highwire
May 2018300Highwire
Jun 2018400Highwire
Jul 2018400Highwire
Aug 2018800Highwire
Aug 2018377pmc
Sep 20181012Highwire
Oct 2018601Highwire
Nov 2018940Highwire
Dec 20181300Highwire
Jan 20191110Highwire
Feb 20191530Highwire
Mar 2019400Highwire
Apr 2019710Highwire
May 20191600Highwire
Jun 2019800Highwire
Jul 2019600Highwire
Aug 2019410Highwire
Sep 20191402Highwire
Oct 20191320Highwire
Nov 20191901Highwire
Dec 2019800Highwire
Jan 2020911Highwire
Feb 2020300Highwire
Mar 2020711Highwire
Apr 20201000Highwire
May 2020500Highwire
Jun 2020700Highwire
Jul 2020900Highwire
Aug 2020500Highwire
Sep 20202220Highwire
Oct 2020700Highwire
Nov 20204310Highwire
Dec 20201520Highwire
Jan 20211302Highwire
Feb 2021922Highwire
Mar 20211500Highwire
Apr 20211021Highwire
May 20211320Highwire
Jun 20211100Highwire
Jul 20211321Highwire
Aug 20211330Highwire
Sep 20211221Highwire
Oct 20211200Highwire
Nov 20211400Highwire
Dec 20211401Highwire
Jan 20221000Highwire
Feb 20222500Highwire
Mar 20221100Highwire
Apr 20221200Highwire

Cited By...

  • 31 Citations
  • Google Scholar

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • ABSTRACT
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Related Articles

  • Spotlight on the November 20 Issue
  • The A's and B's of the ABC's of stroke mechanisms and recurrence in pediatric ischemic stroke

Topics Discussed

  • All Pediatric
  • All Cerebrovascular disease/Stroke
  • Vasculitis
  • Infarction
  • Childhood stroke

Alert Me

  • Alert me when eletters are published
Neurology: 98 (21)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise