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July 17, 2012; 79 (3) Articles

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

Michael Schöll, Anders Wall, Steinunn Thordardottir, Daniel Ferreira, Nenad Bogdanovic, Bengt Långström, Ove Almkvist, Caroline Graff, Agneta Nordberg
First published June 13, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31825fdf18
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Article Information

vol. 79 no. 3 229-236
DOI: 
https://doi.org/10.1212/WNL.0b013e31825fdf18
PubMed: 
22700814
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 2, 2011
  • Accepted December 1, 2011
  • First Published June 13, 2012.

Article Versions

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. Michael Schöll, PhD,
    2. Anders Wall, PhD,
    3. Steinunn Thordardottir, MD,
    4. Daniel Ferreira, MSc,
    5. Nenad Bogdanovic, MD, PhD,
    6. Bengt Långström, PhD,
    7. Ove Almkvist, PhD,
    8. Caroline Graff, MD, PhD and
    9. Agneta Nordberg, MD, PhD
  1. Michael Schöll, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Gun and Bertil Stohne’s foundation; The Old Servants foundation; The Sigurd and Elsa Goljes foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Anders Wall, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Employee at PET-center, Uppsala univeristy hostpital, Uppsala, Sweden

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Steinunn Thordardottir, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Daniel Ferreira, MSc,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. FPI grant (MICINN, Spain). Grant number: BES-2007-15658

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Nenad Bogdanovic, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bengt Långström, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of labelled Compounds and Radiopharmaceuticals

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Ove Almkvist, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Caroline Graff, MD, PhD and
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Invited speaker at the Lundbecks Alzheimer symposium in Copenhagen, Denmark on “Molecular and genetic aspects of current Alzheimer research- Where are we heading?” November 5th 2009. Invited speaker on “Alzheimer’s disease and genetic counseling” at the National Dementia Days for staff in health care, in Örebro, 2010, May 19th, Sweden. Invited speaker on “Alzheimer’s disease and genetic counseling” at the National Dementia Sympoisum in Oslo, Norway 2010October 8th for clinicians and researchers in Norway.

    Editorial Boards:

    1. NONE

    Patents:

    1. Nr: JP2005-044776 and Nr: JP2010-48067 Issued in Japan. Diagnostik tool for dementia based on gene expression in fibroblasts.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. YearFunding Agency 2011-2013Swedish Research Council, no. 21738 research grant

    Research Support, Academic Entities:

    1. YearFunding Agencyrole 2011-2014KID PhD-student funding, KIresearch grant 2006-2011KID PhD-student funding, KI research grant

    Research Support, Foundations and Societies:

    1. YearFunding Agencyrole 2005-2010Swedish Brain Power research grant 2010-2012Swedish Brain Powerresearch grant 2007-2010ALF-project Stockholm County Council research grant, mainly salary support 2006-2011KID PhD-student funding, KI salary funding 2009-2011Marianne and Marcus Wallenbergresearch grant and 3 years for my salary (75%) 2007-2011Other; Stohnes, Gamla tjänarinnor, Alzheimer Fondenresearch grants 2010-2012Postdoc funding from Roche, Geneva Salary support 2010-2011King Gustaf V and Queen Victorias Free masons foundation:500 research grant 2011-2013ALF-project Stockholm County Council research grant, mainly salary support

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Agneta Nordberg, MD, PhD
    10. Scientific Advisory Boards:

    1. Elan Merck GE Healthcare Lundbeck AB Pfizer

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Novartis Merz Bayer Pfizer JansenCilag

    Editorial Boards:

    1. Journal Alzheimer Research advisory board memember Alzheimer Disease and Therapy advisory board member Current Alzheimer Research advisory board member

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Novaris GE Healthcare

    Research Support, Government Entities:

    1. Swedish Research Council

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Knut and Alice Wallenberg foundation Swedish Brain foundation KI Strategic program Brain foundation Swedish Alzheimer foundation Stohnes foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurobiology, Care Sciences, and Society (M.S., S.T., D.F., N.B., O.A., C.G., A.N.), Karolinska Institutet, Stockholm; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.W.), and Department of Biochemistry and Organic Chemistry (B.L.), Uppsala University, Uppsala; Department of Geriatric Medicine (S.T., C.G., A.N.), Karolinska University Hospital Huddinge, Stockholm; and Department of Psychology (O.A.), Stockholm University, Stockholm, Sweden.
  1. Correspondence & reprint requests to Dr. Nordberg: agneta.k.nordberg{at}ki.se
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