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July 24, 2012; 79 (4) Articles

Machine learning algorithms to classify spinal muscular atrophy subtypes

Tuhin Srivastava, Basil T. Darras, Jim S. Wu, Seward B. Rutkove
First published July 11, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182604395
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Article Information

vol. 79 no. 4 358-364
DOI: 
https://doi.org/10.1212/WNL.0b013e3182604395
PubMed: 
22786588
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received November 2, 2011
  • Accepted March 19, 2012
  • First Published July 11, 2012.

Article Versions

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. Tuhin Srivastava, BS,
    2. Basil T. Darras, MD,
    3. Jim S. Wu, MD and
    4. Seward B. Rutkove, MD
  1. Tuhin Srivastava, BS,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Basil T. Darras, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Athena Diagnostics, Honorarium for Virtual Ground Rounds (SMA) - 2010

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Various titles, UpToDate, 1999-present.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. ISIS Pharmaceuticals; Quest Diagnostics Speakers’ Bureaus:; Athena Diagnostics

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. PTC Therapeutics

    Research Support, Government Entities:

    1. NIH/NIAMS, 2P01 NS040828-6A11, co-PI, 2000-2012.; NIH/NINDS, HHSN265200423611C, PI, 2006-2009.; NIH/NINDS, 1U10NS077269, co-PI/PD, 2011-2018.; NIH/NIAMS, 1R01AR060850, co-PI, 2011-2015.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. SMA Foundation, site PI, 2004-present.; Muscular Dystrophy Association, co-PI, 2008-2011.; New England Research Institutes/SMA Foundation, PI, 2008-2009.; Slaney Family Fund for SMA, PI, 2008-2013

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Jim S. Wu, MD and
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Seward B. Rutkove, MD
    5. Scientific Advisory Boards:

    1. Convergence Medical Devices

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. 1. Electrical impedance myography--description of certain aspects of the technique (pending); 2. Electrical impedance myography probe--description of device to collect data

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1. Convergence Medical Devices, Inc (Commercial) 2. Neuralstem, Inc (Commercial)

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institutes of Health, PI, R01NS055099, 2007-2012; National Institutes of Health, PI, K24NS060951, 2008- 2013; National Institutes of Health, PI, R01 AR060850, 2011- 2015; NASA, Co-investigator, 2011-2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Amyotrophic Lateral Sclerosis Association; Spinal Muscular Atrophy Foundation; Center of Intergration of Medicine with Innovative Technology

    Stock/Stock Options/Board of Directors Compensation:

    1. Convergence Medical Devices, Inc.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. Convergence Medical Devices, Inc

    Legal Proceedings:

    1. GlaxoSmithKline, consultant.

  1. From the Departments of Neurology and Radiology (T.S., J.S.W., S.B.R.), Beth Israel Deaconess Medical Center, Boston, MA; and Department of Neurology (B.T.D.), Children's Hospital Boston, Harvard Medical School, Boston, MA.
  1. Correspondence & reprint requests to Dr. Rutkove: srutkove{at}bidmc.harvard.edu
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