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July 31, 2012; 79 (5) Articles

A randomized trial of stress management for the prevention of new brain lesions in MS

David C. Mohr, Jesus Lovera, Ted Brown, Bruce Cohen, Thomas Neylan, Roland Henry, Juned Siddique, Ling Jin, David Daikh, Daniel Pelletier
First published July 11, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182616ff9
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Article Information

vol. 79 no. 5 412-419
DOI: 
https://doi.org/10.1212/WNL.0b013e3182616ff9
PubMed: 
22786596
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 11, 2011
  • Accepted January 17, 2012
  • First Published July 11, 2012.

Article Versions

Copyright & Usage: 
Copyright © 2012 by AAN Enterprises, Inc.

Author Disclosures

    1. David C. Mohr, PhD,
    2. Jesus Lovera, MD,
    3. Ted Brown, MD,
    4. Bruce Cohen, MD,
    5. Thomas Neylan, MD,
    6. Roland Henry, PhD,
    7. Juned Siddique, DrPH,
    8. Ling Jin, MS,
    9. David Daikh, MD and
    10. Daniel Pelletier, MD
  1. David C. Mohr, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. National Institutes of Health

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. R01-MH059708 (Mohr PI)08/00 – 03/12 (last renewal 4/07) R01-HD043323(Mohr- CoPI/Daikh)9/03-10 VA HSR&D IIR03-069-2(Mohr- PI)07/05-09/10 R34 MH078922(Mohr - PI)06/08 - 05/11

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Jesus Lovera, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Received compensation from EMD Serono and TEVA Pharmaceuticals for conducting educational activities for physicians. Speakers’ Bureaus: 1) Biogen Idec 2) Serono

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NCCAM-K23AT004433 PI 5 years

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Ted Brown, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Acorda, honoraria; Pfizer, honoraria; Teva, honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Acorda Therapeutics; Biogen Idec; Bayer Pharmaceutical; Otsuka Pharmaceutical Speakers’ Bureaus:; Pfizer

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Lilly; Acorda; Teva

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. Teva, 2011; Acorda, 2011

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Bruce Cohen, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 1)Bayer speaker honoraria 2)EMD Serono speaker honoraria 3)Pfizer, speaker honoraria 4)Teva Neuroscience speaker honoraria Speakers’ Bureaus: The following apply to the entire period covered by this disclosure: Bayer (Berlex)2008-2010 EMD Serono 2008-2010 Teva Neuroscience 2008-2010

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. Teva Neuroscience: funding for an annual neurology education program sponsored through my department and institution 2008-2011

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Investigator in clinical trials: Biogen-Idec 2008-2011 BMS Medical 20087-2009 EMD Serono 2008-2009 Novartis 2008-2011 Sanofi - Aventis 2008-2009

    Research Support, Government Entities:

    1. clinical research: NINDS 1 U01n NS45719-01A 7/1/05-6/30/09 Clinical investigator-site PI NIAIDv 1U01A169471 12/1/06-11/30/11 Neurologist clinical investigator NICHD NCIRE 725-SW-001/R01HD04 11/1/07-6/30/09 co- investigator HIH RO1 MH080636-01A2 11/1/07-5/31/08 Co-investigator NIAID 5 U01 A035039-15/Mod #40 4/1/04-3/31/10 co- investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Thomas Neylan, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIMH, R01 MH73978, PI, 04/01/05 - 03/31/11 2) NIMH, R34MH077667, PI, 03/01/08 - 02/28/12 3) Dept Defense, W81XWH-09-2-0080,PI, 09/01/09 - 08/31/13

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Roland Henry, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Frontiers in Neuroscience Associate Editor 2 years

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. R01 CA103934 (Vigneron) 4/12/2006 - 02/28/2011 NIH MR DIFFUSION TENSOR IMAGING OF PROSTATE CANCER This project is focused on the application of 1.5T MR diffusion tensor imaging techniques in the clinical assessment of prostate cancer prior to radical prostatectomy. Role: Co-investigator R01 NS066654 (Henry) 09/01/2009 -08/31/2 NIH/NINDS MULTIMODAL CONNECTIVITY FOR SURGICAL MAPPING Improving preoperative determination of eloquent regions with MEG and diffusion MRI fiber tracking. Role: PI R01EB009756 (Xu and Barkovich) 9/01/2009-6/30/2014 NIH/NIBIB DEVELOPMENT OF ADVANCED TECHNIQUES FOR MR OF THE NEWBORN BRAIN The objective of this Bioengineering Partnership Project is to develop 3T MRI hardware and software for the non-invasive characterization of brain maturation and injury in premature and term newborns. Role: Co-investigator R01NS060776 (Mukherjee) 7/01/2009-6/30/2013 NIH/NINDS MACROSTRUCTURAL AND MICROSTRUCTURAL IMAGING BIOMARKERS OF TRAUMATIC BRAIN INJURY The objective of this research proposal is to establish quantitative macrostructural and microstructural imaging biomarkers for predicting patient outcome after TBI.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Lupus Research Institute

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Juned Siddique, DrPH,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. American Statistical Association. Travel reimbursement for being an invited speaker at the 2011 International Conference on Health Policy Statistics.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Ling Jin, MS,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. David Daikh, MD and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) National Institutes of Health (NIAID), Autoimmunity Center of Excellence, Co-Investigator (2008-2011) 2) National Institutes of Health (NIMH), RO1 HDO43323-01, Co-Invesigator, PI, (2004-2010)

    Research Support, Academic Entities:

    1. 1) University of California, San Francisco 2) Department of Veterans Affairs, San Francisco VA Medical Center

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Daniel Pelletier, MD
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. CNS Imaging Consultant, LLC

    Speakers’ Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I have received research grant support from Biogen-Idec over the past two years.

    Research Support, Government Entities:

    1. I receive research grant support from NIH/NINDS R01-NS062885 (PI).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Northwestern University Feinberg School of Medicine (D.C.M., B.C., J.S., L.J.), Chicago, IL; Louisiana State University Health Sciences Center School of Medicine (J.L.), New Orleans; Evergreen Hospital Medical Center (T.B.), Seattle, WA; University of California, San Francisco (T.N., R.H., D.D., D.P.), San Francisco; and San Francisco VA Medical Center (T.N., D.D.), San Francisco, CA.
  1. Correspondence & reprint requests to Dr. Mohr: d-mohr{at}northwestern.edu
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