Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

August 21, 2012; 79 (8) Articles

MRI-leukoaraiosis thresholds and the phenotypic expression of dementia

Catherine C. Price, Sandra M. Mitchell, Babette Brumback, Jared J. Tanner, Ilona Schmalfuss, Melissa Lamar, Tania Giovannetti, Kenneth M. Heilman, David J. Libon
First published July 25, 2012, DOI: https://doi.org/10.1212/WNL.0b013e3182661ef6
Catherine C. Price
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sandra M. Mitchell
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Babette Brumback
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jared J. Tanner
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
MS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ilona Schmalfuss
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melissa Lamar
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tania Giovannetti
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenneth M. Heilman
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David J. Libon
From the Department of Clinical and Health Psychology (C.C.P., S.M.M., J.J.T.), Department of Biostatistics (B.B.), and Department of Neurology (K.M.H.), University of Florida, Gainesville; Department of Radiology (I.S.), North Florida/South Georgia VA, University of Florida, Gainesville; Department of Psychiatry (M.L.), University of Illinois, Chicago; Department of Psychology (T.G.), Temple University, Philadelphia, PA; and Department of Neurology (D.J.L.), Drexel University, College of Medicine, Philadelphia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
MRI-leukoaraiosis thresholds and the phenotypic expression of dementia
Catherine C. Price, Sandra M. Mitchell, Babette Brumback, Jared J. Tanner, Ilona Schmalfuss, Melissa Lamar, Tania Giovannetti, Kenneth M. Heilman, David J. Libon
Neurology Aug 2012, 79 (8) 734-740; DOI: 10.1212/WNL.0b013e3182661ef6

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
502

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: To examine the concept of leukoaraiosis thresholds on working memory, visuoconstruction, memory, and language in dementia.

Methods: A consecutive series of 83 individuals with insidious onset/progressive dementia clinically diagnosed with Alzheimer disease (AD) or small vessel vascular dementia (VaD) completed neuropsychological measures assessing working memory, visuoconstruction, episodic memory, and language. A clinical MRI scan was used to quantify leukoaraiosis, total white matter, hippocampus, lacune, and intracranial volume. We performed analyses to detect the lowest level of leukoaraiosis associated with impairment on the neuropsychological measures.

Results: Leukoaraiosis ranged from 0.63% to 23.74% of participants' white matter. Leukoaraiosis explained a significant amount of variance in working memory performance when it involved 3% or more of the white matter with curve estimations showing the relationship to be nonlinear in nature. Greater leukoaraiosis (13%) was implicated for impairment in visuoconstruction. Relationships between leukoaraiosis, episodic memory, and language measures were linear or flat.

Conclusions: Leukoaraiosis involves specific threshold points for working memory and visuoconstructional tests in AD/VaD spectrum dementia. These data underscore the need to better understand the threshold at which leukoaraiosis affects and alters the phenotypic expression in insidious onset dementia syndromes.

GLOSSARY

AD=
Alzheimer disease;
BET=
Brain Extraction Tool;
CDT=
Clock Drawing Test;
DSC=
dice similarity coefficient;
FLAIR=
fluid-attenuated inversion recovery;
ICV=
intracranial volume;
LA=
leukoaraiosis;
P(r)VLT=
Philadelphia (repeatable) Verbal Learning Test;
UMDNJ=
University of Medicine and Dentistry of New Jersey;
VaD=
vascular dementia;
WM=
white matter.

Footnotes

  • Study funding: Partially supported by NINDS K23NS60660 (C.P.) and Alzheimer's Association IIRG0627542 (D.L.).

  • Editorial, page 726

  • See pages 741 and 748

  • Received October 26, 2011.
  • Accepted February 8, 2012.
  • Copyright © 2012 by AAN Enterprises, Inc.
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. [email protected]
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Hastening the Diagnosis of Amyotrophic Lateral Sclerosis

Dr. Brian Callaghan and Dr. Kellen Quigg

► Watch

Related Articles

  • Imaging markers of incipient dementiaThe white matter matters
  • Trajectory of white matter hyperintensity burden preceding mild cognitive impairment
  • Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI

Topics Discussed

  • All Cognitive Disorders/Dementia
  • All Clinical Neurology
  • MRI
  • Neuropsychological assessment

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Articles
    Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline
    L. C. Silbert, C. Nelson, D. B. Howieson et al.
    Neurology, July 07, 2008
  • Articles
    Association of parental dementia with cognitive and brain MRI measures in middle-aged adults
    S. Debette, P. A. Wolf, A. Beiser et al.
    Neurology, December 09, 2009
  • Article
    Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory
    Ji Won Han, Pauline Maillard, Danielle Harvey et al.
    Neurology, July 30, 2020
  • Articles
    Trajectory of white matter hyperintensity burden preceding mild cognitive impairment
    Lisa C. Silbert, Hiroko H. Dodge, Louie G. Perkins et al.
    Neurology, July 25, 2012
Neurology: 101 (22)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise