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January 01, 2013; 80 (1) Article

Clinical relevance of differential lymphocyte recovery after alemtuzumab therapy for multiple sclerosis

Mark D. Cossburn, Katharine Harding, Gillian Ingram, Tariq El-Shanawany, Adrian Heaps, Trevor P. Pickersgill, Stephen Jolles, Neil P. Robertson
First published December 12, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31827b5927
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Article Information

vol. 80 no. 1 55-61
DOI: 
https://doi.org/10.1212/WNL.0b013e31827b5927
PubMed: 
23243077
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 19, 2012
  • Accepted August 13, 2012
  • First Published December 12, 2012.

Article Versions

Copyright & Usage: 
© 2012 American Academy of Neurology

Author Disclosures

    1. Mark D. Cossburn, MRCP,
    2. Katharine Harding, MRCP,
    3. Gillian Ingram, PhD,
    4. Tariq El-Shanawany, MD,
    5. Adrian Heaps, PhD,
    6. Trevor P. Pickersgill, MBBch,
    7. Stephen Jolles, MD and
    8. Neil P. Robertson, MD
  1. Mark D. Cossburn, MRCP,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Katharine Harding, MRCP,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Travel grant from Biogen Idec to attend theAssociation of British Neurologists Annual Meeting inBrighton, UK, on the 28th and 29th May 2012

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Gillian Ingram, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Tariq El-Shanawany, MD,
    5. Scientific Advisory Boards:

    1. (1) Advisory board, Hayward Medical/Viriopharma(2) Advisory board, Meda/Epipen(3) MonoPepT1De-1b trial data safety monitoring board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Speaker honoraria from ALKTravel funding from ALK, CSL, BPL, Octapharma, Baxter and Grifols

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Adrian Heaps, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 1) Commercial: Phadia UK/Thermo-Fisher): Travel fee and Speaker honoraria (March 2011).

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Phadia UK (Thermo-Fisher): reagent costs for an unrelated study (2010-2012).

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) Association of Clinical Biochemistry (ACB): Scholarship Award 2010 reagent costs for an unrelated study.2) Association of Clinical Biochemistry (ACB): Scholarship Award 2011 reagent costs for an unrelated study.3) National Institute for Social Care and Health Research (NISCHR) Clinical Research Assistantship 2012-2015 for unrelated studies.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Trevor P. Pickersgill, MBBch,
    7. Scientific Advisory Boards:

    1. Served on Advisory Boards for Biogen-Idec and Teva (2009)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Travel and registration fee sponsorship for ECTRIMS 2004-8 (Merck-Serono); AAN 2008/ECTRIMS 2009-10 (Biogen-Idec);ECTRIMS 2011 (Novartis)

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. British Medical Association (Director) - received honoraria and travel expenses

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. Previous owner of stock in Genzyme Corp. 2009-11.

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Stephen Jolles, MD and
    8. Scientific Advisory Boards:

    1. (1) CSL Behring(2)Baxter(3)Shire(4)Octapharma(5)Viropharma(6)Thermofisher(7)Biotest(8)BPL(9)Swedish Orphan Biovitrum(10)Meda

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1)Clinical and Experimental Immunology, Editorial Board, 4 years

    Patents:

    1. (1)Use of IVIg in TB

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) CSL Behring(2)Baxter(3)Shire(4)Octapharma(5)Viropharma(6)Thermofisher(7)Biotest(8)BPL(9)Swedish Orphan Biovitrum(10)Meda

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1)CSL Behring(2)Shire(3)Thermofisher(4)BPL(5)Association of Clinical Biochemists

    Research Support, Government Entities:

    1. (1)NISCHR - 3 year 1/10th salary

    Research Support, Academic Entities:

    1. (1)Honorary Senior Lecturer, UHW(2)Training Program Director Immunology for Wales

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Neil P. Robertson, MD
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Neurology, Journal club editor May 2012 to current

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University (M.D.C., K.H., G.I., N.P.R.), and The Clinical Neurosciences Directorate (T.P.P.) and Department of Immunology, Cardiff and Vale University Local Health Board (T.E.-S., A.H., S.J.), University Hospital of Wales, Cardiff, UK.
  1. Correspondence to Dr. Robertson: robertsonnp{at}cf.ac.uk
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