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January 01, 2013; 80 (1) Article

Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia

Stephen N. Gomperts, Joseph J. Locascio, Dorene Rentz, Andrea Santarlasci, Marta Marquie, Keith A. Johnson, John H. Growdon
First published December 12, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31827b1a07
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Article Information

vol. 80 no. 1 85-91
DOI: 
https://doi.org/10.1212/WNL.0b013e31827b1a07
PubMed: 
23243071
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 20, 2012
  • Accepted August 13, 2012
  • First Published December 12, 2012.

Article Versions

Copyright & Usage: 
© 2012 American Academy of Neurology

Author Disclosures

    1. Stephen N. Gomperts, MD, PhD,
    2. Joseph J. Locascio, PhD,
    3. Dorene Rentz, PhD,
    4. Andrea Santarlasci, BS,
    5. Marta Marquie, MD,
    6. Keith A. Johnson, MD and
    7. John H. Growdon, MD
  1. Stephen N. Gomperts, MD, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Royalties from Prescription for the Boards. 1995, 1998, 2002.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIMH 1K08MH81207 PI 6/1/08 - 5/31/13, NIA 5 U01 AG016976 co-investigator 7/1/07-6/30/09

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. MJFox Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Joseph J. Locascio, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Dorene Rentz, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer Association IIRG-08-90934 Michael J. Fox Foundation for Parkinson's Research

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Andrea Santarlasci, BS,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Marta Marquie, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Caja Madrid Foundation - Scholarship for postgraduate studies

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Keith A. Johnson, MD and
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Pfizer Inc., travel and speaker honoraria

    Editorial Boards:

    1. (1) Journal of Neuroimaging, Associate Editor, 2005-2012

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) The Whole Brain Atlas, Williams and Wilkins, 1999

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) GEHC Ltd; 2) Avid/Lilly ; 3) Bayer-Schering; 4) Pfizer; 5) Elan/Janssen; 6) Bristol-Myers-Squib, 7) Siemens

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. 1) Division of Nuclear Medicine and Molecular Imaging, Department of Imaging, Massachusetts General Hospital, Boston, MA., <5%, 2002-2011; 2) Memory Disorders Unit, Department of Neurology, Brigham and Women's Hospital, Boston, MA., <5%, 1993-2011.

    Research Support, Commercial Entities:

    1. 1) Avid/Lilly; 2) Bristol-Myers-Squib; 3) Janssen (JanssenAI); 4) Pfizer

    Research Support, Government Entities:

    1. 1) NIH/NIA R01 AG037497, principal investigator, 2010-2011; (2) NIH/NIA: R01 AG027435S, co-princpal investigator, 2005-2011; (3) P50 AG00513421, co-investigator, 2002-2011; (4) P01 AG036694 co-principal investigator, 2009-2011; (5) R01 AG021910, co-investigator, 2008-2011; (6) K23 AG033634, sponsor/mentor, 2009-2011; (7) NIH/NINDS R01 NS062028, co-investigator, 2008-2011; (8) NIH/NINDS R01 AG026484, co-investigator, 2010-2011; (9) NIH/NIA R21 AG038994, co-investigator, 2011

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Alzheimer Association ZEN-10-174210, principal investigator, 2010-2011; (2) Alzheimer Association IIRG-08-90934, co-investigator, 2008-2011; (3) American Health Assistance Foundation, co-investigator, 2010-2011

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. John H. Growdon, MD
    8. Scientific Advisory Boards:

    1. Consultant advisor to Neurimmune Company. 2008-12.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board: Archives of Neurology - 2000-present, Neurodegenerative Diseases - 2005-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. Elsevier. The Dementias. 1998 and The Dementias 2. 2007

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA. Co-PI. P50 AG05134 1984-present, NINDS. Co-PI. P50 NS037372 1998-2005, NINDS. PI. R21 NS60310 2007-2009

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. M. J. Fox Foundation. PI. 2008-present.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (S.N.G., J.J.L., D.R., A.S., M.M., K.A.J., J.H.G.) and Radiology (K.A.J.), Massachusetts General Hospital, Boston; and Autonomous University of Barcelona–Medicine Doctoral Studies (M.M.), Barcelona, Spain.
  1. Correspondence to Dr. Growdon: jgrowdon{at}partners.org
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