March 12, 2013; 80 (11) Article
Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease
Annapaola Prestia, Anna Caroli, Wiesje M. van der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte E. Teunissen, Anders E. Wall, Stephen F. Carter, Michael Schöll, Il Han Choo, Agneta Nordberg, Philip Scheltens, Giovanni B. Frisoni
First published February 6, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182872830
Annapaola Prestia
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Anna Caroli
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Wiesje M. van der Flier
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Rik Ossenkoppele
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Bart Van Berckel
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Frederik Barkhof
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Charlotte E. Teunissen
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Anders E. Wall
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Stephen F. Carter
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Michael Schöll
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Il Han Choo
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Agneta Nordberg
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Philip Scheltens
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Giovanni B. Frisoni
From LENITEM–Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., A.C., G.B.F.), IRCCS Centro San Giovanni di Dio FBF, Brescia; Medical Imaging Unit (A.C.), Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Alzheimer Center and Department of Neurology (W.M.v.d.F., R.O., P.S.) and Departments of Epidemiology & Biostatistics (W.M.v.d.F.), Nuclear Medicine and PET Research (R.O., B.V.B.), Radiology (F.B.), and Clinical Chemistry (C.E.T.), VU University Medical Center, Amsterdam, the Netherlands; PET Center, Section of Nuclear Medicine & PET, Department of Radiology, Oncology and Radiation Sciences (A.E.W.), Uppsala University, Uppsala; Karolinska Institutet (S.F.C., M.S., I.H.C.), Alzheimer Neurobiology Center, Stockholm, Sweden; Department of Neuropsychiatry (I.H.C., A.N.), School of Medicine, Chosun University, Gwangju, Republic of Korea; and Department of Geriatric Medicine (A.N.), Karolinska University Hospital Huddinge, Stockholm, Sweden.
Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease
Annapaola Prestia, Anna Caroli, Wiesje M. van der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte E. Teunissen, Anders E. Wall, Stephen F. Carter, Michael Schöll, Il Han Choo, Agneta Nordberg, Philip Scheltens, Giovanni B. Frisoni
Neurology Mar 2013, 80 (11) 1048-1056; DOI: 10.1212/WNL.0b013e3182872830
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