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March 12, 2013; 80 (11) Article

Elevation of proinflammatory cytokines in patients with Aicardi-Goutières syndrome

Asako Takanohashi, Morgan Prust, Jichuan Wang, Heather Gordish-Dressman, Miriam Bloom, Gillian I. Rice, Johanna L. Schmidt, Yanick J. Crow, Pierre Lebon, Taco W. Kuijpers, Kanneboyina Nagaraju, Adeline Vanderver
First published February 13, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182872694
Asako Takanohashi
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Morgan Prust
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Jichuan Wang
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Heather Gordish-Dressman
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Miriam Bloom
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Gillian I. Rice
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Johanna L. Schmidt
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Yanick J. Crow
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Pierre Lebon
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Taco W. Kuijpers
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Kanneboyina Nagaraju
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Adeline Vanderver
From the Center for Genetic Medicine Research (A.T., H.G.-D., J.L.S., K.N., A.V.), Department of Neurology (M.P., J.L.S., A.V.), Biostatistics and Informatics Unit, Center for Clinic and Community Research (J.W.), and Hospitalist Medicine Division (M.B.), Children's National Medical Center, Washington, DC; Genetic Medicine (G.I.R., Y.J.C.), University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals, Manchester, UK; Hopital Cochin-Saint Vincent de Paul (P.L.), Service de Virologie and EA1833 Université Paris-Descartes, Paris, France; and Academisch Medisch Centrum (T.W.K.), Universiteit Vrije Amsterdam, Amsterdam, the Netherlands.
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Full PDF
Citation
Elevation of proinflammatory cytokines in patients with Aicardi-Goutières syndrome
Asako Takanohashi, Morgan Prust, Jichuan Wang, Heather Gordish-Dressman, Miriam Bloom, Gillian I. Rice, Johanna L. Schmidt, Yanick J. Crow, Pierre Lebon, Taco W. Kuijpers, Kanneboyina Nagaraju, Adeline Vanderver
Neurology Mar 2013, 80 (11) 997-1002; DOI: 10.1212/WNL.0b013e3182872694

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