March 19, 2013; 80 (12) Article
Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI
Stephanie J.B. Vos, Ineke A. van Rossum, Frans Verhey, Dirk L. Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B. Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visser
First published February 27, 2013, DOI: https://doi.org/10.1212/WNL.0b013e318288690c
Stephanie J.B. Vos
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Ineke A. van Rossum
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Frans Verhey
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Dirk L. Knol
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Hilkka Soininen
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Lars-Olof Wahlund
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Harald Hampel
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Magda Tsolaki
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Lennart Minthon
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Giovanni B. Frisoni
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Lutz Froelich
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Flavio Nobili
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Wiesje van der Flier
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Kaj Blennow
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Robin Wolz
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Philip Scheltens
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Pieter Jelle Visser
From the Department of Psychiatry and Neuropsychology (S.J.B.V., F.V., P.J.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht; Departments of Neurology (I.A.v.R., W.v.d.F., P.S., P.J.V.) and Epidemiology and Biostatistics (D.L.K.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (H.S.), University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Department of NVS (L.-O.W.), Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; Department of Psychiatry (H.H.), Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany; Aristotle University of Thessaloniki (M.T.), Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece; Clinical Memory Research Unit (L.M.), Department of Clinical Sciences Malmö, Lund University, Sweden; IRCCS San Giovanni di Dio Fatebenefratelli (G.B.F.), Laboratory of Epidemiology and Neuroimaging and Translational Research Unit, Brescia, Italy; Department of Geriatric Psychiatry (L.F.), Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany; Clinical Neurophysiology Service (F.N.), Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy; Clinical Neurochemistry Laboratory (K.B.), Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Computing (R.W.), Imperial College London, UK.
Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI
Stephanie J.B. Vos, Ineke A. van Rossum, Frans Verhey, Dirk L. Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B. Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visser
Neurology Mar 2013, 80 (12) 1124-1132; DOI: 10.1212/WNL.0b013e318288690c
Citation Manager Formats
Make Comment
See Comments
Downloads
526
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Disputes & Debates: Rapid online correspondence
No comments have been published for this article.
NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Advertisement