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April 09, 2013; 80 (15) Article

Molecular and pathologic insights from latent HIV-1 infection in the human brain

Paula Desplats, Wilmar Dumaop, David Smith, Anthony Adame, Ian Everall, Scott Letendre, Ronald Ellis, Mariana Cherner, Igor Grant, Eliezer Masliah
First published March 13, 2013, DOI: https://doi.org/10.1212/WNL.0b013e31828c2e9e
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Article Information

vol. 80 no. 15 1415-1423
DOI: 
https://doi.org/10.1212/WNL.0b013e31828c2e9e
PubMed: 
23486877
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 14, 2012
  • Accepted in final form November 29, 2012
  • First Published March 13, 2013.

Article Versions

Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Paula Desplats, PhD,
    2. Wilmar Dumaop, BS,
    3. David Smith, MD,
    4. Anthony Adame, BS,
    5. Ian Everall, PhD,
    6. Scott Letendre, MD,
    7. Ronald Ellis, MD, PhD,
    8. Mariana Cherner, PhD,
    9. Igor Grant, MD and
    10. Eliezer Masliah, MD
  1. Paula Desplats, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. UCSD

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Wilmar Dumaop, BS,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. David Smith, MD,
    4. Scientific Advisory Boards:

    1. Pfizer Scientific Board for HIV medications 2008

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. editorial advisory boardThe Open AIDS Journal 2006 to presentThe Open Infectious Diseases Journal 2008 to present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant and Board MemberSymmunity LLC

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The investigator is supported by National Institutes ofHealth grants MH083552, AI077304, AI69432, MH62512,AI27670, AI38858, AI43638, AI43752, AI047745, UCSD Centersfor AIDS Research Viral Pathogenesis Core (AI36214)and HIVInfection of the San Diego Veterans Affairs HealthcareSystem (10-92-035) from 2007 to present.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Symmunity LLC

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Anthony Adame, BS,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Ian Everall, PhD,
    6. Scientific Advisory Boards:

    1. Abbott Laboratories Pte Ltd.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Abbott Laboratories Pte Ltd., Commercial, honorariumAstraZeneca, Commercial, honorarium

    Editorial Boards:

    1. Molecular PsychiatryTranslational PsychiatryJournal of VirologyHIV/AIDS - research adn Palliative CareNeurobevioral HIV Medicine

    Patents:

    1. Detection of biomarkers for neuropsychiatric disorders, US20080261218A method comprising: performing a statistical analysis ona first set of gene data expressed in brain tissueobtained from a first control set not having aneuropsychiatric disorder and a second set of gene dataexpressed in central nervous system tissue obtained from afirst set of individuals having a neuropsychiatricdisorder to identify a first set of one or moredifferentially expressed genes; performing a statisticalanalysis on a third set of gene data expressed in bloodobtained from a second control set not having aneuropsychiatric disorder and a fourth set of gene dataexpressed in blood obtained from a second set ofindividuals having a neuropsychiatric disorder to identifya second set of one or more differentially expressedgenes; and comparing the first set of one or moredifferentially expressed genes to the second set of one ormore differentially expressed genes to identify a commonset of one or more differentially expressed genes.

    Publishing Royalties:

    1. Neurology of AIDS, 3rd Edition, OUP 2012

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Abbott Laboratories Pte Ltd.

    Research Support, Government Entities:

    1. National Health and Medical Research Council, AustraliaCommonwealth Government of Australia

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Scott Letendre, MD,
    7. Scientific Advisory Boards:

    1. (1) GlaxoSmithKline, 2011(2) Merck & Co., Inc., 2012

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Lucid Group UK, Speaker Honorarium(2) Stratagen, Speaker Honorarium

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Merck & Co., Inc.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) GlaxoSmithKline, Paid to the University of California(2) Merck & Co., Inc., Paid to the University of California(3) Tibotec/Janssen, Paid to the University of California

    Research Support, Government Entities:

    1. (1) NIH, U01 MH083506, consultant, 2011, 2012(2) NIH, R01 MH58076, co-investigator, 2011, 2012(3) NIH, P01 DA12065, co-investigator, 2011, 2012(4) NIH, R01 MH73433, co-investigator, 2011, 2012(5) NIH, N01 MH22005, co-investigator, 2011, 2012(6) NIH, P30 MH62512, co-investigator, 2011, 2012(7) NIH, R01 MH78748, co-investigator, 2011, 2012(8) NIH, R21 MH85610, principal investigator, 2011, 2012(9) NIH, R01, MH92225, principal investigator, 2011, 2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Ronald Ellis, MD, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Abbott International, speaker honoraria

    Editorial Boards:

    1. Journal of Neuroimmune Pharmacology, Editorial Advisory Board, 2007-2010

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NeurogesX, Inc. - Consultant fee for FDA Advisory panel

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH, P30 MH62512, Co-investigator, 2010-2015 (2) NIH, N01 HHSN271201000036C, Co-investigator, 2010-2015(3) NIH, P50 DA26306, Co-investigator, 2009-2014(4) NIH, R01 MH095621, Co-investigator, 2011-2016 (5) NIH, U01 MH83506, Co-investigator, 2008-2013(6) NIH, R01 MH83552, Co-investigator, 2008-2013(7) NIH, R01 MH085608, Co-investigator, 2009-2013(8) NIH, R01 MH94159, Co-investigator, 2011-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. Abbott Laboratories, stock held by spouseJohnson and Johnson, stock held by spouse

    Legal Proceedings:

    1. NONE

  8. Mariana Cherner, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. travel to the annual meeting of the InternationalNeuropsychological Society as Chair of a Society committee

    Editorial Boards:

    1. Journal of the International Neuropsychological Society,member of editorial board, 2004-2012

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) NIH, MH81482, PI, 2007-present(2) NIH, DA27513, PI, 2009-2012(3) NIH, DA26334, PI, 2009-2012(4) NIH, MH62512, Co-I, 2006-present(5) NIH, DA26306, Co-I, 2009-present(6) NIH, MH58076, C0-I, 2006-2011

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Igor Grant, MD and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Abbott Pharmaceuticals speaker fee

    Editorial Boards:

    1. (1)Journal of the International NeuropsychologicalSociety, Associate Editor, 2002-2004, (2) Journal ofNeurovirology, Associate Editor, 2002-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Abbott Pharmaceuticals

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIDA, DA26306, PI, 2009-present, (2) NIMH, MH83506,PI, 2002-present, (3) NIA, AG15301, PI, 2002-present, (4)NIMH, HHSN271201000036C, PI, 2010-present, (5) NIMH,HHSN271201000030C, PI, 2010-present, (6) NIMH, MH62512,Co-I, 2011-present, (7) NIMH, MH78748, Co-I, 2007-present,(8) NIMH, MH83552, Co-I, 2008-present, (9) NIMH, MH094159,Co-I, 2011-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Eliezer Masliah, MD
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. EVER Pharma and NPT sponsored travel to international scientific meeting

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Neotope Biosciences, NPT, Neurophage

    Research Support, Government Entities:

    1. NIH NIA AG5131, AG18440, MH062962, AG043384

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurosciences (P.D., A.A., R.E., E.M.), Pathology (W.D., E.M.), Medicine (D.S., S.L.), and Psychiatry (I.E., M.C., I.G.), University of California San Diego, La Jolla. Dr. Everall is currently affiliated with the Department of Psychiatry, University of Melbourne, Melbourne, Australia.
  1. Correspondence to Dr. Masliah: emasliah{at}ucsd.edu
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