Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis
Clinical and MRI data at onset and clinical follow-up at 1 year were collected for 1,165 patients with clinically isolated syndromes. Involvement of specific white matter tracts traversed by fibers involved in motor function and near the corpus callosum was associated with a higher risk of clinical conversion to multiple sclerosis.
See p. 234; Editorial, p. 230
Clinically feasible MTR is sensitive to cortical demyelination in MS
This study sets the stage for detection of presently undetectable cortical demyelination, which may exceed white matter demyelination in patients with MS. Clinically feasible magnetization transfer ratio (MTR) imaging …
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