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Ross syndrome is a rare autonomic disorder described by Ross in 19581 and characterized by tonic pupil, hyporeflexia, and segmental anhidrosis. A postganglionic cholinergic nerve degeneration of unknown cause underlies this condition2 although erratic association with Sjögren3 and antinuclear antibody4 positivity has led some authors to hypothesize immunologic causes. Familial cases have not been reported.
Footnotes
Author contributions: Dr. Nolano: study concept and design, analysis and interpretation, critical revision of the manuscript for important intellectual content, study supervision. Dr. Provitera: study concept and design, analysis and interpretation, critical revision of the manuscript for important intellectual content. Dr. Donadio: study concept and design, critical revision of the manuscript for important intellectual content. Dr. Stancanelli: acquisition of data, analysis and interpretation. Dr. Saltalamacchia: acquisition of data, analysis and interpretation. Dr. Caporaso: acquisition of data, analysis and interpretation. Dr. Santoro: critical revision of the manuscript for important intellectual content, study supervision.
Study funding: No targeted funding reported.
The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received June 29, 2012.
- Accepted September 19, 2012.
- © 2013 American Academy of Neurology
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