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Abstract
Objective: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).
Methods: Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting.
Results: Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.
Conclusions: Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.
GLOSSARY
- AD=
- Alzheimer disease;
- DMT1=
- divalent metal transporter 1;
- FPN1=
- ferroportin 1;
- HC=
- healthy controls;
- IRE=
- iron-responsive element;
- IRP1=
- iron regulatory protein 1;
- PD=
- Parkinson disease;
- SN=
- substantia nigra;
- TfR1=
- transferrin receptor 1
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
- Received March 25, 2012.
- Accepted September 24, 2012.
- © 2013 American Academy of Neurology
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