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January 29, 2013; 80 (5) Article

Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease

Xiaojun Yu, Tingting Du, Ning Song, Qing He, Yong Shen, Hong Jiang, Junxia Xie
First published January 9, 2013, DOI: https://doi.org/10.1212/WNL.0b013e31827f0ebb
Xiaojun Yu
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Tingting Du
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Ning Song
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Qing He
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Yong Shen
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Hong Jiang
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Junxia Xie
From the Department of Physiology (X.Y., T.D., N.S., Q.H., H.J., J.X.), Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Center for Advanced Therapeutic Strategies for Brain Disorders (Y.S.), Roskamp Institute, Sarasota, FL; and Haldeman Laboratory of Molecular and Cellular Neurobiology (Y.S.), Sun Health Research Institute, Sun City, AZ.
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Citation
Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease
Xiaojun Yu, Tingting Du, Ning Song, Qing He, Yong Shen, Hong Jiang, Junxia Xie
Neurology Jan 2013, 80 (5) 492-495; DOI: 10.1212/WNL.0b013e31827f0ebb

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Abstract

Objective: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).

Methods: Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting.

Results: Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.

Conclusions: Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.

GLOSSARY

AD=
Alzheimer disease;
DMT1=
divalent metal transporter 1;
FPN1=
ferroportin 1;
HC=
healthy controls;
IRE=
iron-responsive element;
IRP1=
iron regulatory protein 1;
PD=
Parkinson disease;
SN=
substantia nigra;
TfR1=
transferrin receptor 1

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received March 25, 2012.
  • Accepted September 24, 2012.
  • © 2013 American Academy of Neurology
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Disputes & Debates: Rapid online correspondence

  • Re:Iron levels and the temporal cortex
    • Hong Jiang, jhkyk@163.com
    Submitted March 27, 2013
  • Iron levels and the temporal cortex
    • Osamu Kano, M.D., Ph.D., Department of Neurology, Toho University Omori Medical Centerosamukano2@gmail.com
    • Ken Ikeda, Yasuo Iwasaki, Tokyo, Japan
    Submitted March 19, 2013
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