Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

February 12, 2013; 80 (7) Article

Prognostic factors of motor impairment, disability, and quality of life in newly diagnosed PD

Daan C. Velseboer, Mark Broeders, Bart Post, Nan van Geloven, Johannes D. Speelman, Ben Schmand, Rob J. de Haan, Rob M.A. de Bie, on behalf of the CARPA Study Group
First published January 23, 2013, DOI: https://doi.org/10.1212/WNL.0b013e318281cc99
Daan C. Velseboer
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Broeders
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bart Post
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nan van Geloven
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johannes D. Speelman
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ben Schmand
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rob J. de Haan
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rob M.A. de Bie
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
From the Department of Neurology (D.C.V., J.D.S., B.S., R.M.A.d.B.), Clinical Research Unit (N.v.G., R.J.d.H.), Academic Medical Center, and Department of Brain and Cognition (M.B., B.S.), University of Amsterdam; and Department of Neurology (B.P.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Full PDF
Citation
Prognostic factors of motor impairment, disability, and quality of life in newly diagnosed PD
Daan C. Velseboer, Mark Broeders, Bart Post, Nan van Geloven, Johannes D. Speelman, Ben Schmand, Rob J. de Haan, Rob M.A. de Bie, on behalf of the CARPA Study Group
Neurology Feb 2013, 80 (7) 627-633; DOI: 10.1212/WNL.0b013e318281cc99

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
515

Share

  • Article
  • Figures & Data
  • Info & Disclosures
  • CME Course
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: In Parkinson disease (PD), the rate of clinical progression is highly variable. To date, there are conflicting findings concerning the prognostic factors influencing the rate of progression. Methodologic issues such as the use of selected patients from therapeutic trials, and short durations of follow-up probably underlie this problem. We therefore designed a prospective follow-up study of a cohort of newly diagnosed patients with PD.

Methods: A cohort of 129 patients with newly diagnosed PD was assessed at baseline, and 1, 2, 3, and 5 years later. The rate of progression and its prognostic factors on the level of motor impairments, disability, and quality of life were investigated using linear mixed-model analysis.

Results: Annual increase of motor impairments measured with the Unified Parkinson's Disease Rating Scale–Motor Examination was estimated to be 2.46 points (95% confidence interval: 2.05–2.88). The main determinants of faster increase of motor impairments were male sex and cognitive dysfunction at the time of diagnosis. The main determinants of faster increase of disability were higher age at onset, cognitive dysfunction, and the presence of levodopa-nonresponsive motor symptoms at the time of diagnosis. No clinically relevant determinants were found for the decrease in quality of life.

Conclusion: This study shows the importance of nondopaminergic symptoms at the time of diagnosis, because these symptoms are the main determinants of increased disability in the first 5 years of the disease.

GLOSSARY

ALDS=
Academic Medical Center Linear Disability Scale;
CI=
confidence interval;
HADS=
Hospital Anxiety and Depression Scale;
PD=
Parkinson disease;
PDQL=
Parkinson's Disease Quality of Life;
UPDRS-ME=
Unified Parkinson's Disease Rating Scale–Motor Examination

Footnotes

  • CARPA Study Group coinvestigators are listed on the Neurology® Web site at www.neurology.org.

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Supplemental data at www.neurology.org

  • Received June 13, 2012.
  • Accepted October 11, 2012.
  • © 2013 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
  • CME Course

More Online

CME Course

Related Articles

  • Diagnostic shifts in ALS?From clinical specter to imaging spectra
  • Biomarkers for PDHow can we approach complexity?
  • Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS
  • Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease
  • Warfarin treatment and thrombolysisHow to persuade procrastinators?
  • tPA and warfarinTime to move forward
  • Neighborhood socioeconomic status and stroke mortalityDisentangling individual and area effects
  • The border-land of epilepsy—Revisited

Topics Discussed

  • Cohort studies
  • Quality of life
  • Parkinson's disease/Parkinsonism
  • Natural history studies (prognosis)
  • Risk factors in epidemiology

Alert Me

  • Alert me when eletters are published
Neurology: 99 (1)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise