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February 26, 2013; 80 (9) Article

Nonmotor fluctuations in Parkinson disease

Severity and correlation with motor complications

Alexander Storch, Christine B. Schneider, Martin Wolz, Yannic Stürwald, Angelika Nebe, Per Odin, Andreas Mahler, Gerd Fuchs, Wolfgang H. Jost, K. Ray Chaudhuri, Rainer Koch, Heinz Reichmann, Georg Ebersbach
First published January 30, 2013, DOI: https://doi.org/10.1212/WNL.0b013e318285c0ed
Alexander Storch
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Christine B. Schneider
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Martin Wolz
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Yannic Stürwald
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Angelika Nebe
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Per Odin
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Andreas Mahler
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Gerd Fuchs
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Wolfgang H. Jost
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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K. Ray Chaudhuri
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Rainer Koch
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Heinz Reichmann
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Georg Ebersbach
From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
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Full PDF
Citation
Nonmotor fluctuations in Parkinson disease
Severity and correlation with motor complications
Alexander Storch, Christine B. Schneider, Martin Wolz, Yannic Stürwald, Angelika Nebe, Per Odin, Andreas Mahler, Gerd Fuchs, Wolfgang H. Jost, K. Ray Chaudhuri, Rainer Koch, Heinz Reichmann, Georg Ebersbach
Neurology Feb 2013, 80 (9) 800-809; DOI: 10.1212/WNL.0b013e318285c0ed

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Article Information

vol. 80 no. 9 800-809
DOI: 
https://doi.org/10.1212/WNL.0b013e318285c0ed
PubMed: 
23365054

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received April 3, 2012
  • Accepted October 24, 2012
  • First Published January 30, 2013.

Article Versions

  • Previous version (January 30, 2013 - 13:03).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Alexander Storch, MD,
    2. Christine B. Schneider, MD,
    3. Martin Wolz, MD,
    4. Yannic Stürwald,
    5. Angelika Nebe, MD,
    6. Per Odin, MD, PhD,
    7. Andreas Mahler, MD,
    8. Gerd Fuchs, MD,
    9. Wolfgang H. Jost, MD,
    10. K. Ray Chaudhuri, DSc, MD,
    11. Rainer Koch, MD, PhD,
    12. Heinz Reichmann, MD, PhD and
    13. Georg Ebersbach, MD
  1. Alexander Storch, MD,
  2. Scientific Advisory Boards:
    1. Member of advisory boards: Boehringer Ingelheim; Ingelheim, Germany (since 2006), Cephalon, Munich, Germany, (since 2006), Valeant Pharma, Frankfurt, Germany (since 2007), UCB Schwarz Pharma, Monheim, Germany (since 2007), Lundbeck Phrma, Hamburg, Germany, and Teva Pharma, Mörfelden-Walldorf, Germany (since 2009), Merz Pharma, Frankfurt, Germany (since 2011), Archimedes Pharma, Munich, Germany (since 2012).

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. Travel money for visiting a meeting from Boehringer, Ingelheim, Germany (2009), and Teva Pharma, Mörfelden, Germany (2012).

    Editorial Boards:
    1. Editorial board member of Stem Cells, Stem Cells, International, The Open Biotechnology Journal, The European Neurological Journal

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. 1) Employment at the German Centre for Neurodegenerative, Diseases (DZNE), Dresden (non-profit, goverment institution), 2) Honoraria for presentations from Cephalon, Lundbeck, Boehringer Ingelheim, Teva, UCB, Meda, Abbott, GlaxoSmithKline, GE HealthCare, Novartis, NeuroConsil, Carus Management, Gruenenthal, Orion, Bayer HealthCare, Medtronic, SWEMODIS. Payment for manuscript preparation from Archimedes, Munich, Germany.

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. I have received unrestricted research grants from Boehringer Ingelheim, Germany, Pfizer Pharma, Germany, Teva Pharma Germany, and UCB Pharma, Germany.

    Research Support, Government Entities:
    1. I have received grant money from the Bundesministerium für Bildung und Forschung, Germany, Federal Ministry of Economy, Germany, the Helmholtz Association, and the Deutsche Forschungsgemeinschaft (DFG).

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. I have received grant money from the Thyssen Foundation, Germany, the Roland-Ernst Foundation, Germany, the International Parkinson Foundation, Germany, the NA, Advocacy, UK, and the NCL foundation, Gemany.

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Christine B. Schneider, MD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Martin Wolz, MD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. honoraria for presentations from Boehringer Ingelheim, GlaxoSmithKline, Valeant, MEDA Pharma, Medtronic, TEVA and UCB Pharma

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Yannic Stürwald,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Angelika Nebe, MD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Per Odin, MD, PhD,
  12. Scientific Advisory Boards:
    1. Abbott, Stada

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. Abbott, UCB, Stada

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Abbott

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Andreas Mahler, MD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Gerd Fuchs, MD,
  16. Scientific Advisory Boards:
    1. 1 UCB, 2 Boehringer, 3 Orion

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. 1 UCB, 2 Boehringer

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Wolfgang H. Jost, MD,
  18. Scientific Advisory Boards:
    1. Scientific advisory board: Allergan, Boehringer Ingelheim,Desitin, GlaxoSmithKline, Merz

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Editor-in-chief: Basal Ganglia

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. K. Ray Chaudhuri, DSc, MD,
  20. Scientific Advisory Boards:
    1. Scientific advisory board for Abbott, Boehringer-Ingelheim, GSK, Serrono, Teva, UCB, Britannia pharmaceuticals between 2007-2012 and received honorarium for scientific advise.

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Parkinson's disease and related disorder. Editorial board since 2009, European Editor Basal ganglia, Editorial board: Journal of Parkinson's Disease

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. Honoraria for advisor in scientific advisory boards as listed above. Honoraria for lectures in international scientific meetings (EFNS, Swedish Movement Disorders Society, LIMPE Italy 2007-2009, MDS (Paris)) MDS 2010,2011, EFNS 2011, WPD 2010, WFN PRD 2011

    Consultancies:
    1. 1: PDNMG, 2: Mundipharma

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Research support for a clinical research nurse from UCB Pharma (2008-2009). Solvay (clinical fellow) Educational grant from UCB, Abbott, Boehringer for EUROPAR - an European Multicentre PD non motor studies programme

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Rainer Koch, MD, PhD,
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  23. Heinz Reichmann, MD, PhD and
  24. Scientific Advisory Boards:
    1. Abbott, Cephalon, Novartis, TEVA, Lundbeck, GSK, Boehringer Ingelheim, Schering/Bayer Health Care, UCB/Schwarz Pharma, Desitin, Merck-Serono, Solvay

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. for advisory board meetings or lectures. Cephalon, Novartis, TEVA, Lundbeck, GSK, Boehringer Ingelheim, Schering/Bayer Health Care, Pfizer, UCB/Schwarz Pharma, Desitin,Solvay.

    Editorial Boards:
    1. UCB/Schwarz Pharma, GSK

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. Cephalon, Novartis, TEVA, Lundbeck, GSK, Boehringer Ingelheim, Schering/Bayer Health Care, Pfizer, UCB/Schwarz Pharma, Desitin,Solvay (2008/2009)

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  25. Georg Ebersbach, MD
  26. Scientific Advisory Boards:
    1. Desitin Pharma, Novartis Pharma, Boehringer Pharma, Archimedes Pharma, Orion Pharma, Britannia Pharma

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. Desitin Pharma, MEDA Pharma, Glaxo SmithKline Pharma, Boehringer Pharma, Novartis Pharma, Archimedes Pharma, Orion Pharma, TEVA Pharma, UCB Pharma, Abbot Pharma

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Novartis Pharma, Archimedes Pharma, Licher GmbH, Britannia Pharma

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Deutsche Parkinson Vereinigung (patient organisation)

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology, Division of Neurodegenerative Diseases (A.S., C.B.S., M.W., Y.S.), Department of Medical Informatics and Biometry (R.K.), and Department of Neurology (H.R.), Dresden University of Technology, Dresden; German Center for Neurodegenerative Diseases (DZNE) (A.S.), Dresden; Movement Disorders Clinic (A.N., G.E.), Beelitz-Heilstätten; Department of Neurology (P.O., A.M.), Klinikum Bremerhaven, Bremerhaven, Germany; Department of Neurology (P.O), University Hospital, Lund, Sweden; Parkinson Clinic Wolfach (G.F.), Wolfach; Department of Neurology (W.H.J.), Deutsche Klinik für Diagnostik, Wiesbaden, Germany; and National Parkinson Foundation Centre of Excellence (K.R.C.), Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK.
  1. Correspondence to Dr. Storch: alexander.storch{at}neuro.med.tu-dresden.de
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