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July 02, 2013; 81 (1) Article

Prospective study of restless legs syndrome and mortality among men

Yanping Li, Wei Wang, John W. Winkelman, Atul Malhotra, Jing Ma, Xiang Gao
First published June 12, 2013, DOI: https://doi.org/10.1212/WNL.0b013e318297eee0
Yanping Li
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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Wei Wang
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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John W. Winkelman
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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Atul Malhotra
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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Jing Ma
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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Xiang Gao
From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
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Full PDF
Citation
Prospective study of restless legs syndrome and mortality among men
Yanping Li, Wei Wang, John W. Winkelman, Atul Malhotra, Jing Ma, Xiang Gao
Neurology Jul 2013, 81 (1) 52-59; DOI: 10.1212/WNL.0b013e318297eee0

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Article Information

vol. 81 no. 1 52-59
DOI: 
https://doi.org/10.1212/WNL.0b013e318297eee0
PubMed: 
23761622

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received November 8, 2012
  • Accepted in final form March 8, 2013
  • First Published June 12, 2013.

Article Versions

  • Previous version (June 12, 2013 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Yanping Li, PhD,
    2. Wei Wang, MD, PhD,
    3. John W. Winkelman, MD, PhD,
    4. Atul Malhotra, MD,
    5. Jing Ma, MD, PhD and
    6. Xiang Gao, MD, PhD
  1. Yanping Li, PhD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Wei Wang, MD, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. John W. Winkelman, MD, PhD,
  6. Scientific Advisory Boards:
    1. Zeo Incorporated

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Sleep, Associate Editor, 2008- Sleep Medicine, Editorial Board 2004- CNS Drugs, Editorial Board 2004-

    Patents:
    1. NONE

    Publishing Royalties:
    1. Fundamentals of Psychiatric Sleep Medicine, 2010

    Employment, Commercial Entity:
    1. Brigham and Women's Hospital, physician

    Consultancies:
    1. 1) Impax Pharmaceuticals, 2) UCB Pharma

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. 1) GlaxoSmithKline, 2) Impax Pharmaceuticals, 3) UCB Pharma

    Research Support, Government Entities:
    1. National Institute of Mental Health R01MH095792-01A1

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. Axinn, Veltrop and Harkrider LLP, 2009-2012

  7. Atul Malhotra, MD,
  8. Scientific Advisory Boards:
    1. I have received consulting and/or research income from NIH, AHA, SGS, SHC, Pfizer, Philips, Apnex, Apnicure

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. editorial board of AJRCCM and Chest; associate editor at Sleep

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. I have received consulting and/or research income from NIH, AHA, SGS, SHC, Pfizer, Philips, Apnex, Apnicure

    Speakers' Bureaus:
    1. NONE

    Other activities:
    1. I have grant funding from NIH and AHA. I previously had research and/or consulting income from Philips, SHC, SGS, Apnex, Apnicure and Pfizer but none is relevant to the present manuscript. I have relinquished all outside personal income since May 2012

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. i have multiple nih grants but none related to this topic

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Jing Ma, MD, PhD and
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Xiang Gao, MD, PhD
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Has reported consultancy relationship with Teva

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From The Channing Laboratory (Y.L., J.M., X.G.) and the Division of Sleep Medicine (J.W.W., A.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Otolaryngology (W.W.), Tianjin First Central Hospital, Tianjin, China; and Department of Nutrition (W.W., X.G.), Harvard School of Public Health, Boston, MA.
  1. Correspondence to Dr. Gao: xgao{at}hsph.harvard.edu or Dr. Li: yanping.li{at}channing.harvard.edu
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  • Lipoprotein(a)-activated autoimmunity: possible link between restless legs syndrome and mortality risk?
    • Altan Onat, Emeritus Professor, Department of Cardiology, Cerrahpa?a Medical Faculty, Istanbul Universityalt_onat@yahoo.com.tr
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    Submitted July 24, 2013
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