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September 03, 2013; 81 (10) Article

Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people

Farzaneh A. Sorond, Shelley Hurwitz, David H. Salat, Douglas N. Greve, Naomi D.L. Fisher
First published August 7, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a351aa
Farzaneh A. Sorond
From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
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Shelley Hurwitz
From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
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David H. Salat
From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
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Douglas N. Greve
From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
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Naomi D.L. Fisher
From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
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Full PDF
Citation
Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people
Farzaneh A. Sorond, Shelley Hurwitz, David H. Salat, Douglas N. Greve, Naomi D.L. Fisher
Neurology Sep 2013, 81 (10) 904-909; DOI: 10.1212/WNL.0b013e3182a351aa

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Article Information

vol. 81 no. 10 904-909
DOI: 
https://doi.org/10.1212/WNL.0b013e3182a351aa
PubMed: 
23925758

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received November 29, 2012
  • Accepted in final form May 6, 2013
  • First Published August 7, 2013.

Article Versions

  • Previous version (August 7, 2013 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Farzaneh A. Sorond, MD, PhD,
    2. Shelley Hurwitz, PhD,
    3. David H. Salat, PhD,
    4. Douglas N. Greve, PhD and
    5. Naomi D.L. Fisher, MD
  1. Farzaneh A. Sorond, MD, PhD,
  2. Scientific Advisory Boards:
    1. North American Thrombosis Forum, Non-profit organization, Scientific Advisory Board 2007- present

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Supplied Cocoa

    Research Support, Government Entities:
    1. (1) NIA: PI K23-AG030967 2008-2013

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Shelley Hurwitz, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. David H. Salat, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Janssen Pharmaceuticals

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Biogen Idec

    Research Support, Government Entities:
    1. NIHNS042861; NIHRRP4114075; NIHR21026104; NIHAG026484; NIHAG028676; R01NR010827;

    Research Support, Academic Entities:
    1. Executive Committee on Research (MGH)

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Douglas N. Greve, PhD and
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Naomi D.L. Fisher, MD
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Mars Inc. supplied cocoa

    Research Support, Government Entities:
    1. NIH: NHLBI, RO1 HL089570-01, PI 01/01/09-12/31/13 NCE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology, Stroke Division (F.A.S.), and Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (S.H., N.D.L.F.), Brigham and Women's Hospital; Neuroimaging Research for Veterans Center (D.H.S.), and Geriatric Research, Education and Clinical Center (D.H.S.), VA Boston Healthcare System; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging (D.H.S., D.N.G.), Department of Radiology, Massachusetts General Hospital; and Harvard Medical School (F.A.S., S.H., D.H.S., D.N.G., N.D.L.F.), Boston, MA.
  1. Correspondence to Dr. Sorond: fsorond{at}partners.org
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Cited By...

  • 79 Citations
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Letters: Rapid online correspondence

  • Cocoa may inhibit adenosine receptors modulating the blood brain barrier at the neurovascular unit improving cognition and white matter integrity.
    • Steven R Brenner, Physician retired., St. Louis University Dept. Neurology and PsychiatrySBren20979@aol.com
    • None
    Submitted November 05, 2013
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