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September 24, 2013; 81 (13) Views & Reviews

Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children

Deborah I. Friedman, Grant T. Liu, Kathleen B. Digre
First published August 21, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a55f17
Deborah I. Friedman
From the University of Texas Southwestern Medical Center (D.I.F.), Dallas; Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania (G.T.L.), Philadelphia; and the University of Utah (K.B.D.), Salt Lake City.
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Grant T. Liu
From the University of Texas Southwestern Medical Center (D.I.F.), Dallas; Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania (G.T.L.), Philadelphia; and the University of Utah (K.B.D.), Salt Lake City.
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Kathleen B. Digre
From the University of Texas Southwestern Medical Center (D.I.F.), Dallas; Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania (G.T.L.), Philadelphia; and the University of Utah (K.B.D.), Salt Lake City.
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Citation
Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children
Deborah I. Friedman, Grant T. Liu, Kathleen B. Digre
Neurology Sep 2013, 81 (13) 1159-1165; DOI: 10.1212/WNL.0b013e3182a55f17

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Abstract

The pseudotumor cerebri syndrome (PTCS) may be primary (idiopathic intracranial hypertension) or arise from an identifiable secondary cause. Characterization of typical neuroimaging abnormalities, clarification of normal opening pressure in children, and features distinguishing the syndrome of intracranial hypertension without papilledema from intracranial hypertension with papilledema have furthered our understanding of this disorder. We propose updated diagnostic criteria for PTCS to incorporate advances and insights into the disorder realized over the past 10 years.

GLOSSARY

BMI=
body mass index;
ICP=
intracranial pressure;
IIH=
idiopathic intracranial hypertension;
LP=
lumbar puncture;
MRV=
magnetic resonance venography;
PTC=
pseudotumor cerebri;
PTCS=
pseudotumor cerebri syndrome

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial, page 1112

  • Received January 3, 2013.
  • Accepted in final form May 24, 2013.
  • © 2013 American Academy of Neurology
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Letters: Rapid online correspondence

  • REPLY to Drs. Wall and Corbett
    • Denorah I Friedman, Professor, Neurology & Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TXDeborah.Friedman@utsouthwestern.edu
    • Grant Liu, Philadelphia, PA, Kathleen Digre, Salt Lake City, UT
    Submitted January 24, 2014
  • The Modified Dandy Criteria for Idiopathic Intracranial Hypertension, No Need to Fix What is not Broken
    • Michael Wall, Professor, University of Iowamichael-wall@uiowa.edu
    • Michael Wall, M.D. Iowa City, IA; James J. Corbett, M.D., Jackson, MS
    Submitted January 10, 2014
  • Re: IDIOPATHIC INTRACRANIAL HYPERTENSION: PAPILLEDEMA OR NOT? THIS IS THE QUESTION!
    • Deborah Friedman, Professor, University of Texas Southwestern Mecial CenterDeborah.Friedman@utsouthwestern.edu
    • Kathleen Digre MD, Salt Lake City, UT; Grant Liu MD, Philadelphia, PA
    Submitted January 02, 2014
  • Papilledema and CSF opening pressure below 28 cm H2O. Is it pseudotumor cerebri though?
    • Daniel Tibussek, Child Neurologist, Department of Neurology, Hospital for Sick Children, Toronto, Canadadaniel.tibussek@sickkids.ca
    • Felix Distelmaier, Duesseldorf, Germany
    Submitted January 02, 2014
  • IDIOPATHIC INTRACRANIAL HYPERTENSION: PAPILLEDEMA OR NOT? THIS IS THE QUESTION!
    • Claudio Liguori, Medical Doctor, Department of Systems Medicine, University of "Tor Vergata", Rome, Italydott.claudioliguori@yahoo.it
    • Claudio Liguori, Rome, Italy; Andrea Romigi, Rome, Italy; Maria Albanese, Rome, Italy; Maria G Marciani, Rome, Italy; Fabio Placidi, Rome, Italy
    Submitted November 07, 2013
  • REPLY TO Dr. Dasheiff
    • Deborah I. Friedman, Professor, University of Texas Southwestern Medical CenterDeborah.Friedman@utsouthwestern.edu
    • Deborah Friedman, Dallas, TX; Grant Liu, Philadelphia, PA; Kathleen Digre, Salt Lake City, UT
    Submitted November 05, 2013
  • Ducks in a row
    • Richard Dasheiff, Neurologist, locums tenensrdasheiff@yahoo.com
    Submitted October 16, 2013
  • Reply to Dr. De Simone et al
    • Deborah I Friedman, Professor of Neurology & Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical CenterDeborah.Friedman@utsouthwestern.edu
    • Deborah I. Friedman, Dallas, TX; Grant T. Liu, Philadelphia, PA; Kathleen B. Digre, Salt Lake City, UT
    Submitted September 13, 2013
  • Cerebrospinal fluid opening pressure in IIH diagnosis
    • Roberto De Simone, Headache Centre Director, Dept. of Neurosciences. University Federico II of Naples - Italyrodesimo@unina.it
    • Roberto De Simone, Naples, Italy; Angelo Ranieri, Naples, Italy; Silvana Montella, Naples, Italy
    Submitted September 11, 2013
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