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September 24, 2013; 81 (13) Clinical/Scientific Notes

Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation

Nikunj K. Patel, Nicola Pavese, Shazia Javed, Gary R. Hotton, David J. Brooks, Steven S. Gill
First published August 14, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a55ea5
Nikunj K. Patel
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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Nicola Pavese
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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Shazia Javed
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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Gary R. Hotton
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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David J. Brooks
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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Steven S. Gill
From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.
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Citation
Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation
Nikunj K. Patel, Nicola Pavese, Shazia Javed, Gary R. Hotton, David J. Brooks, Steven S. Gill
Neurology Sep 2013, 81 (13) 1176-1178; DOI: 10.1212/WNL.0b013e3182a55ea5

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We previously reported clinical improvement, increase in putamen [18F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic fibers following chronic intraputaminal delivery of glial cell line–derived neurotrophic factor (GDNF) in idiopathic Parkinson disease (PD).1–3 We now provide clinical and PET evidence of persistent efficacy lasting for at least 3 years following cessation of GDNF infusion in a patient with PD. This is a single-case observational study, providing Class IV evidence.

Footnotes

  • Supplemental data at www.neurology.org

  • Author contributions: N.K. Patel: research project: conception, organization, execution, including clinical assessments and analysis of clinical data; manuscript: writing of the first draft together with S. Javed. N. Pavese: research project: conception, execution including PET scanning and analysis; manuscript: review and critique of first draft, writing of the revised manuscript together with N.K. Patel and S. Javed. S. Javed: research project: conception, execution including clinical assessments; manuscript: writing of the first draft together with N.K. Patel. G.R. Hotton: research project: conception, execution including PET scanning; manuscript: review and critique of first draft. D.J. Brooks: research project: conception; manuscript: review and critique. S.S. Gill: research project: conception; manuscript: review and critique.

  • Study funding: No targeted funding reported.

  • Disclosure: N. Patel, N. Pavese, S. Javed, and G. Hotton report no disclosures. D. Brooks is employed part-time by GE Healthcare. S. Gill is a consultant to Renishaw plc and Medtronic Inc. Go to Neurology.org for full disclosures.

  • Received August 20, 2012.
  • Accepted in final form May 16, 2013.
  • © 2013 American Academy of Neurology
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