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October 08, 2013; 81 (15) Article

Incidence and prevalence of small-fiber neuropathy

A survey in the Netherlands

Martine J.H. Peters, Mayienne Bakkers, Ingemar S.J. Merkies, Janneke G.J. Hoeijmakers, Elisabeth P.M. van Raak, Catharina G. Faber
First published August 30, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a8236e
Martine J.H. Peters
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Mayienne Bakkers
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Ingemar S.J. Merkies
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Janneke G.J. Hoeijmakers
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Elisabeth P.M. van Raak
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Catharina G. Faber
From the Department of Neurology (M.J.H.P., M.B., I.S.J.M., J.G.J.H., E.P.M.v.R., C.G.F.), Maastricht University Medical Center, Maastricht; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.
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Citation
Incidence and prevalence of small-fiber neuropathy
A survey in the Netherlands
Martine J.H. Peters, Mayienne Bakkers, Ingemar S.J. Merkies, Janneke G.J. Hoeijmakers, Elisabeth P.M. van Raak, Catharina G. Faber
Neurology Oct 2013, 81 (15) 1356-1360; DOI: 10.1212/WNL.0b013e3182a8236e

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Abstract

Objective: To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands.

Methods: In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuropathy Center between January 2006 and December 2011 to calculate minimum incidence and prevalence rates.

Results: A total of 88 patients were diagnosed with SFN (mean age 56.9 years, SD 11.8, range 34–81; 44.3% women, 55.7% men). The overall minimum incidence over 2010 and 2011 was 11.73 (95% confidence interval 7.12–18.22) cases/100,000 inhabitants/year. The overall minimum prevalence was 52.95 (95% confidence interval 42.47–65.23) cases/100,000. Incidence and prevalence rates were higher in men than in women, as were the rates in elderly patients compared with younger patients.

Conclusions: The minimum incidence and prevalence rates of SFN are presented. We found that SFN is more frequently seen in men and more often diagnosed in elderly patients. These rates probably are an underestimation and are expected to increase in the coming years, since the awareness of SFN is increasing worldwide.

GLOSSARY

CIDP=
chronic inflammatory demyelinating polyneuropathy;
GBS=
Guillain-Barré syndrome;
IENFD=
intraepidermal nerve fiber density;
MUMC=
Maastricht University Medical Center;
SFN=
small-fiber neuropathy

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received November 30, 2012.
  • Accepted in final form July 10, 2013.
  • © 2013 American Academy of Neurology
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  • Incidence and prevalence of small-fiber neuropathy: A survey in the Netherlands
    • Peter James Dyck, MD, Mayo Clinic, Rochester, MNdyck.peter@mayo.edu
    Submitted September 27, 2013
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