October 22, 2013; 81 (17) Article
Encephalitis and GABAB receptor antibodies
Novel findings in a new case series of 20 patients
Romana Höftberger, Maarten J. Titulaer, Lidia Sabater, Balazs Dome, Anita Rózsás, Balazs Hegedus, Mir Alireza Hoda, Viktoria Laszlo, Hendrik Jan Ankersmit, Lutz Harms, Sabas Boyero, Alicia de Felipe, Albert Saiz, Josep Dalmau, Francesc Graus
First published September 25, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a9585f
Romana Höftberger
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Maarten J. Titulaer
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Lidia Sabater
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Balazs Dome
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Anita Rózsás
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Balazs Hegedus
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Mir Alireza Hoda
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Viktoria Laszlo
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Hendrik Jan Ankersmit
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Lutz Harms
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Sabas Boyero
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Alicia de Felipe
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Albert Saiz
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Josep Dalmau
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Francesc Graus
From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.
Encephalitis and GABAB receptor antibodies
Novel findings in a new case series of 20 patients
Romana Höftberger, Maarten J. Titulaer, Lidia Sabater, Balazs Dome, Anita Rózsás, Balazs Hegedus, Mir Alireza Hoda, Viktoria Laszlo, Hendrik Jan Ankersmit, Lutz Harms, Sabas Boyero, Alicia de Felipe, Albert Saiz, Josep Dalmau, Francesc Graus
Neurology Oct 2013, 81 (17) 1500-1506; DOI: 10.1212/WNL.0b013e3182a9585f
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