Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

December 03, 2013; 81 (23) Article

Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults

Daniel A. Nation, Steven D. Edland, Mark W. Bondi, David P. Salmon, Lisa Delano-Wood, Elaine R. Peskind, Joseph F. Quinn, Douglas R. Galasko
First published November 13, 2013, DOI: https://doi.org/10.1212/01.wnl.0000436935.47657.78
Daniel A. Nation
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven D. Edland
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark W. Bondi
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David P. Salmon
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa Delano-Wood
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elaine R. Peskind
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph F. Quinn
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas R. Galasko
From the Veterans Affairs San Diego Healthcare System (D.A.N., M.W.B., L.D.-W.), San Diego; Departments of Neurosciences (S.D.E., D.P.S., D.R.G.) and Psychiatry (M.W.B., L.D.-W.), University of California, San Diego, La Jolla, CA; VA Puget Sound Health Care System (E.R.P.), Mental Illness Research, Education, and Clinical Center, Seattle; Departments of Psychiatry and Behavioral Sciences (E.R.P.), University of Washington School of Medicine, Seattle, WA; Department of Neurology (J.F.Q.), Oregon Health and Science University, Portland; and Portland VA Medical Center (J.F.Q.), Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults
Daniel A. Nation, Steven D. Edland, Mark W. Bondi, David P. Salmon, Lisa Delano-Wood, Elaine R. Peskind, Joseph F. Quinn, Douglas R. Galasko
Neurology Dec 2013, 81 (23) 2024-2027; DOI: 10.1212/01.wnl.0000436935.47657.78

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
576

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: The current study examined the association between pulse pressure (PP) and CSF-based biomarkers for Alzheimer disease, including β-amyloid 1–42 (Aβ1–42) and phosphorylated tau (P-tau) protein, in cognitively normal older adults.

Methods: One hundred seventy-seven cognitively normal, stroke-free older adult participants (aged 55–100 years) underwent blood pressure assessment for determination of PP (systolic − diastolic blood pressure) and lumbar puncture for measurement of CSF Aβ1–42 and P-tau. Pearson correlations and multiple linear regression, controlling for age, sex, APOE genotype, and body mass index, evaluated the relationship between PP and Alzheimer disease biomarkers.

Results: PP elevation was associated with increased P-tau (r = 0.23, p = 0.002), reduced Aβ1–42 (r = −0.19, p = 0.01), and increased P-tau to Aβ1–42 ratio (r = 0.27, p < 0.001). After controlling for covariates, PP remained associated with P-tau (β = 0.18, p = 0.0196) and P-tau to Aβ1–42 ratio (β = 0.0016, p < 0.001) but was no longer associated with Aβ1–42 (β = −0.1, p = 0.35). Post hoc multivariate analyses indicated that increased PP was associated with all biomarkers in younger participants (aged 55–70 years) (Aβ1–42: p = 0.050; P-tau: p = 0.003; P-tau to Aβ ratio: p = 0.0007) but not older participants (aged 70–100 years).

Conclusions: PP elevation is associated with increased CSF P-tau and decreased Aβ1–42 in cognitively normal older adults, suggesting that pulsatile hemodynamics may be related to amyloidosis and tau-related neurodegeneration. The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life.

GLOSSARY

Aβ1–42=
β-amyloid 1–42;
AD=
Alzheimer disease;
BMI=
body mass index;
BP=
blood pressure;
PP=
pulse pressure;
P-tau=
phosphorylated tau;
UCSD=
University of California, San Diego

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received May 7, 2013.
  • Accepted in final form September 4, 2013.
  • © 2013 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Topics Discussed

  • Alzheimer's disease

Alert Me

  • Alert me when eletters are published
Neurology: 98 (24)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise