July 16, 2013; 81 (3) Views & Reviews
APOE genotype and MRI markers of cerebrovascular disease
Systematic review and meta-analysis
Sabrina Schilling, Anita L. DeStefano, Perminder S. Sachdev, Seung Hoan Choi, Karen A. Mather, Charles D. DeCarli, Wei Wen, Peter Høgh, Naftali Raz, Rhoda Au, Alexa Beiser, Philip A. Wolf, José Rafael Romero, Yi-Cheng Zhu, Kathryn L. Lunetta, Lindsay Farrer, Carole Dufouil, Lewis H. Kuller, Bernard Mazoyer, Sudha Seshadri, Christophe Tzourio, Stéphanie Debette
First published July 15, 2013, DOI: https://doi.org/10.1212/WNL.0b013e31829bfda4
Sabrina Schilling
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Anita L. DeStefano
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Perminder S. Sachdev
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Seung Hoan Choi
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Karen A. Mather
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Charles D. DeCarli
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Wei Wen
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Peter Høgh
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Naftali Raz
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Rhoda Au
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Alexa Beiser
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Philip A. Wolf
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
José Rafael Romero
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Yi-Cheng Zhu
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Kathryn L. Lunetta
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Lindsay Farrer
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Carole Dufouil
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Lewis H. Kuller
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Bernard Mazoyer
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Sudha Seshadri
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Christophe Tzourio
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
Stéphanie Debette
From the Department of Epidemiology (S. Schilling, S.D.), Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines, Versailles; Inserm U708 (S. Schilling, Y.-C.Z., C.D., C.T., S.D.), Neuroepidemiology, Salpêtrière Hospital, Paris; University of Bordeaux Segalen (S. Schilling, C.D., B.M., C.T.), Bordeaux, France; Department of Biostatistics, Boston University School of Public Health (A.L.D., S.H.C., A.B.), and Department of Neurology (R.A., A.B., P.A.W., J.R.R., L.F., S. Seshadri, S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA; Neuropsychiatric Institute (P.S.S., W.W.), Prince of Wales Hospital, Randwick, NSW; Centre for Healthy Brain Ageing (P.S.S., K.A.M.), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neurology and Center for Neuroscience (C.D.D.), University of California at Davis, Sacramento; Department of Neurology (P.H.), Copenhagen University Hospital, Roskilde, Denmark; Institute of Gerontology and Department of Psychology (N.R.), Wayne State University, Detroit, MI; Department of Biostatistics (K.L.L.), Boston University School of Public Health, Boston; Departments of Medicine (Biomedical Genetics), Ophthalmology, Epidemiology, and Biostatistics (L.F.), Boston University Schools of Medicine and Public Health, Boston, MA; Department of Epidemiology (L.H.K.), GSPH, University of Pittsburgh, Pittsburgh, PA; and CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen (B.M.), France.
APOE genotype and MRI markers of cerebrovascular disease
Systematic review and meta-analysis
Sabrina Schilling, Anita L. DeStefano, Perminder S. Sachdev, Seung Hoan Choi, Karen A. Mather, Charles D. DeCarli, Wei Wen, Peter Høgh, Naftali Raz, Rhoda Au, Alexa Beiser, Philip A. Wolf, José Rafael Romero, Yi-Cheng Zhu, Kathryn L. Lunetta, Lindsay Farrer, Carole Dufouil, Lewis H. Kuller, Bernard Mazoyer, Sudha Seshadri, Christophe Tzourio, Stéphanie Debette
Neurology Jul 2013, 81 (3) 292-300; DOI: 10.1212/WNL.0b013e31829bfda4
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