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July 30, 2013; 81 (5) Article

Discontinuation of statin therapy associates with Parkinson disease

A population-based study

Yen-Chieh Lee, Chin-Hsien Lin, Ruey-Meei Wu, Min-Shung Lin, Jou-Wei Lin, Chia-Hsuin Chang, Mei-Shu Lai
First published July 24, 2013, DOI: https://doi.org/10.1212/WNL.0b013e31829d873c
Yen-Chieh Lee
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Chin-Hsien Lin
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Ruey-Meei Wu
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Min-Shung Lin
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Jou-Wei Lin
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Chia-Hsuin Chang
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Mei-Shu Lai
From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
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Full PDF
Citation
Discontinuation of statin therapy associates with Parkinson disease
A population-based study
Yen-Chieh Lee, Chin-Hsien Lin, Ruey-Meei Wu, Min-Shung Lin, Jou-Wei Lin, Chia-Hsuin Chang, Mei-Shu Lai
Neurology Jul 2013, 81 (5) 410-416; DOI: 10.1212/WNL.0b013e31829d873c

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Article Information

vol. 81 no. 5 410-416
DOI: 
https://doi.org/10.1212/WNL.0b013e31829d873c
PubMed: 
23884037

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 16, 2012
  • Accepted in final form April 1, 2013
  • First Published July 24, 2013.

Article Versions

  • Previous version (July 24, 2013 - 13:01).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Yen-Chieh Lee, MD*,
    2. Chin-Hsien Lin, MD, PhD*,
    3. Ruey-Meei Wu, MD, PhD,
    4. Min-Shung Lin, MD,
    5. Jou-Wei Lin, MD, PhD,
    6. Chia-Hsuin Chang, MD, PhD and
    7. Mei-Shu Lai, PhD
  1. Yen-Chieh Lee, MD*,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Chin-Hsien Lin, MD, PhD*,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Ruey-Meei Wu, MD, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Min-Shung Lin, MD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Jou-Wei Lin, MD, PhD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Chia-Hsuin Chang, MD, PhD and
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. This study was supported in part by Taiwan Ministry of Education grant 98HP0021

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Mei-Shu Lai, PhD
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Family Medicine (Y.-C.L., M.-S.L), Cathay General Hospital, Taipei; the Departments of Neurology (C.-H.L., R.-M.W.) and Medicine (C.-H.C.), National Taiwan University Hospital, Taipei; Department of Medicine, College of Medicine (J.-W.L., C.-H.C.), and Institute of Preventive Medicine, College of Public Health (C.-H.C., M.-S.L.), National Taiwan University, Taipei; and Cardiovascular Center (J.-W.L.), National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan.
  1. Correspondence to Dr. Lin: jouweilin{at}yahoo.com.tw or Dr. Chang: chiahsuin123{at}yahoo.com.tw
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