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August 20, 2013; 81 (8) Article

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

Jasmeer P. Chhatwal, Aaron P. Schultz, Keith Johnson, Tammie L.S. Benzinger, Clifford Jack, Beau M. Ances, Caroline A. Sullivan, Stephen P. Salloway, John M. Ringman, Robert A. Koeppe, Daniel S. Marcus, Paul Thompson, Andrew J. Saykin, Stephen Correia, Peter R. Schofield, Christopher C. Rowe, Nick C. Fox, Adam M. Brickman, Richard Mayeux, Eric McDade, Randall Bateman, Anne M. Fagan, Allison M. Goate, Chengjie Xiong, Virginia D. Buckles, John C. Morris, Reisa A. Sperling
First published July 24, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a1aafe
Jasmeer P. Chhatwal
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Aaron P. Schultz
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Keith Johnson
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Tammie L.S. Benzinger
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Clifford Jack Jr
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Beau M. Ances
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Caroline A. Sullivan
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Stephen P. Salloway
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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John M. Ringman
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Robert A. Koeppe
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Daniel S. Marcus
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Paul Thompson
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Andrew J. Saykin
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Stephen Correia
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Peter R. Schofield
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Christopher C. Rowe
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Nick C. Fox
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Adam M. Brickman
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Richard Mayeux
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Eric McDade
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Randall Bateman
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Anne M. Fagan
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Allison M. Goate
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Chengjie Xiong
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Virginia D. Buckles
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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John C. Morris
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Reisa A. Sperling
From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of Biostatistics (C.X.), Washington University School of Medicine, St. Louis, MO; Department of Radiology (C.J.), Mayo Clinic, Rochester, MN; Department of Neurology, Butler Hospital (S.P.S.), and Department of Psychiatry (S.C.), Brown University School of Medicine, Providence, RI; Department of Neurology (J.M.R., P.T.), Easton Center for Alzheimer's Disease Research, University of California, Los Angeles; Department of Radiology (R.A.K.), University of Michigan School of Medicine, Ann Arbor; Department of Radiology (S.J.S.), IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis; Neuroscience Research Australia (P.R.S.), Sydney; School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; Departments of Nuclear Medicine and Centre for PET (C.C.R.), Austin Health, University of Melbourne, Australia; Department of Neurology (N.C.F.), University College London, UK; Department of Neurology (A.M.B., R.M.), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (E.M.), University of Pittsburgh School of Medicine, PA; and Department of Neurology (C.A.S., R.A.S.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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Full PDF
Citation
Impaired default network functional connectivity in autosomal dominant Alzheimer disease
Jasmeer P. Chhatwal, Aaron P. Schultz, Keith Johnson, Tammie L.S. Benzinger, Clifford Jack, Beau M. Ances, Caroline A. Sullivan, Stephen P. Salloway, John M. Ringman, Robert A. Koeppe, Daniel S. Marcus, Paul Thompson, Andrew J. Saykin, Stephen Correia, Peter R. Schofield, Christopher C. Rowe, Nick C. Fox, Adam M. Brickman, Richard Mayeux, Eric McDade, Randall Bateman, Anne M. Fagan, Allison M. Goate, Chengjie Xiong, Virginia D. Buckles, John C. Morris, Reisa A. Sperling
Neurology Aug 2013, 81 (8) 736-744; DOI: 10.1212/WNL.0b013e3182a1aafe

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  • Article
    • Abstract
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    • METHODS
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