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August 27, 2013; 81 (9) Resident and Fellow Section

Teaching NeuroImages: Sarcoidosis presenting as longitudinally extensive myelitis

Excellent response to infliximab

Naila Goenka, Nagagopal Venna
First published August 26, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a2cc03
Naila Goenka
From the Department of Neurology, Massachusetts General Hospital, Boston.
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Nagagopal Venna
From the Department of Neurology, Massachusetts General Hospital, Boston.
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Teaching NeuroImages: Sarcoidosis presenting as longitudinally extensive myelitis
Excellent response to infliximab
Naila Goenka, Nagagopal Venna
Neurology Aug 2013, 81 (9) e61; DOI: 10.1212/WNL.0b013e3182a2cc03

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A 44-year-old man presented with 2 weeks of progressive right body numbness, weakness, and circumferential burning sensation around his trunk. MRI spine demonstrated longitudinally extensive myelitis (figure 1). MRI brain and laboratory investigations were normal except for CSF lymphocytic pleocytosis (9 leukocytes/mm3). CT revealed hilar and mediastinal lymphadenopathy, which on biopsy showed noncaseating granulomas suggestive of sarcoidosis. As the patient had multiple clinical relapses on steroids, he was treated with infliximab infusions (5 mg/kg every 4 weeks) and had complete clinical and radiologic resolution after 1 year (figure 2). Myelitis as the presenting feature of sarcoidosis is exceptionally rare and responds to infliximab.1,2

Figure 1
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Figure 1 Pretreatment MRI

Sagittal T2-weighted image (A) demonstrates confluent hyperintensity extending from the upper cervical to the upper thoracic spinal cord. On postgadolinium T1-weighted image (B), there is multifocal, patchy enhancement.

Figure 2
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Figure 2 Posttreatment MRI

Sagittal T2-weighted image (A) demonstrates complete resolution of the hyperintensity and associated resolution of the postgadolinium enhancement (B).

AUTHOR CONTRIBUTIONS

N.G. reviewed the clinical case and prepared the manuscript and figures. N.V. supervised the clinical care and commented critically on the manuscript. Both authors approved the final version.

STUDY FUNDING

No targeted funding reported.

DISCLOSURE

The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

  • © 2013 American Academy of Neurology

REFERENCES

  1. 1.↵
    1. Dolhun R,
    2. Sriram S
    . Neurosarcoidosis presenting as longitudinally extensive transverse myelitis. J Clin Neurosci 2009;16:595–597.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Moravan M,
    2. Segal BM
    . Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil. Neurology 2009;72:337–340.
    OpenUrlAbstract/FREE Full Text

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